2012 Fiscal Year Final Research Report
Gene expression profiling of the bone healing responsefor clinical application of nanotextured titanium implants
| Project/Area Number |
23890143
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KURODA Shingo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (40332796)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ナノ加工 / 骨治癒 / 遺伝子発現 / マイクロアレイ |
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| Research Abstract |
Untreated and H2SO4/H2O2-treated machined-surface titanium alloy implants were placed in rat tibiae. Samples were processed for DNA microarray analysis and histomorphometry. At both 3 and 5 days, the gene expression profile of the healing tissue around nanotextured implants differed from that around machined surface ones or control empty holes, and on day 5 were accompanied by increase in bone-implant contact. While some standard pathways, such as the immune response, predominated a number of unclassified genes were also implicated. In conclusion, nanotexture elicits an initial gene response that is more complex than so far suspected and that favors healing at the bone-implant interface.
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