2012 Fiscal Year Final Research Report
Physiological roles of the HVCN1 channel in osteoclast
| Project/Area Number |
23890145
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Ehime University |
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Principal Investigator |
SASAKI Mari 愛媛大学, 大学院・医学系研究科, 助教 (80435817)
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| Project Period (FY) |
2011 – 2012
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| Keywords | イメージング / イオンチャネル |
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| Research Abstract |
Experimental methods for analyzing the osteoclast function wasestablished. For in vitro experiment, osteoclast precursor was co-cultured with osteoblast to differentiate to osteoclast. For in vivo experiment, mechanical testing machine was made for tibia loading. Using this machine the increasing of bone mass was evaluated. To study membrane potential of osteoclast, membrane potential change was measured by imaging technique.
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