2012 Fiscal Year Final Research Report
Transglutaminase-catalyzed Crosslinking Suppresses Innate Immune Signaling in the Drosophila Gut
| Project/Area Number |
23890147
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Kyushu University |
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Principal Investigator |
SHIBATA Toshio 九州大学, 大学院・理学研究院, 助教 (00614257)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 自然免疫 |
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| Research Abstract |
Mammalian transglutaminases (TGases) play importantroles in numerous physiological phenomena such as blood coagulation and skin formation via protein-protein crosslinking. We revealed that TGase-catalyzed protein-protein crosslinking suppresses the immune signaling pathway to maintaina buffered threshold required for immune tolerance against commensal microbes.
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