2012 Fiscal Year Final Research Report
SUMOylation of small G proteins in malignant melanomas
| Project/Area Number |
23890198
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 悪性黒色腫 / SUMO / NACC1 / RAC1 / Small G蛋白 / HDAC6 |
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| Research Abstract |
NACC1 is a member of pluripotent transcription factor, and associates with malignant phenotypes of tumor cells. The present study investigated that the molecular mechanisms of NACC1 in malignant melanomas. We represented that NACC1 directly bound to cortactin, and deacetylated cortactin. This deacetylation introduced acceleration of motility and invasion of tumor cells. The SUMOlylation occurred at NACC1-K167 site, but did not in RAC1. CYLD1 induced-RAC1 activation has been also demonstrated in melanoma cells. These results suggested that NACC1 related proteins may regulated motility and invasion activities of melanoma cells.
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Research Products
(6 results)
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[Journal Article] Downregulation ofmicroRNA -211 is involved in expression of preferentially expressed antigen ofmelanoma in melanoma cells2011
Author(s)
Sakurai E, Maesawa C, Shibazaki M, Yasuhira S, Oikawa H, Sato M, Tsunoda K,Ishikawa Y, Watanabe A, Takahashi K, Akasaka T, Masuda T
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Journal Title
Int J Oncol
Volume: 39(3)
Pages: 665-72
DOI
Peer Reviewed
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[Journal Article] Nucleusaccumbens-associated 1 contributes to cortactin deacetylation and augments the migration of melanoma cells2011
Author(s)
Tsunoda K, Oikawa H, Tada H, Tatemichi Y, Muraoka S, Miura S, Shibazaki M,Maeda F, Takahashi K, Akasaka T, Masuda T, Maesawa C
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Journal Title
J Invest Dermatol
Volume: 131(8)
Pages: 1710-9
DOI
Peer Reviewed
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