2023 Fiscal Year Research-status Report
Artificial Intelligence analysis of the immune-checkpoint and immuno-oncology in B-cell non-Hodgkin lymphoma
| Project/Area Number |
23K06454
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| Research Institution | Tokai University |
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Principal Investigator |
カレーラス ジュアキム 東海大学, 医学部, 講師 (90637191)
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| Project Period (FY) |
2023-04-01 – 2026-03-31
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| Keywords | lymphoma / targeted sequencing / immuno-oncology / immune microenvironment / immune checkpoint / molecular pathology / hematological neoplasia / NGS |
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| Outline of Annual Research Achievements |
BCL6-rearrangement (BCL6-R) is associated with a favorable prognosis of follicular lymphoma (FL), but the mechanism is unknown. We analyzed the clinicopathological, immune microenvironment (immune checkpoint, immuno-oncology markers), and mutational profiles of 10 BCL6-R-positive FL, and 19 BCL6-R-positive diffuse large B-cell lymphoma (DLBCL) cases (both BCL2-R and MYC-R negative). A custom-made panel included 168 genes related to aggressive B-cell lymphomas and FL. Both BCL6-R-positive FL and BCL6-R-positive DLBCL had a common mutational profile; but also, differences. DLBCL cases had a higher density of microenvironment markers.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The project is progressing well, and as expected.
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| Strategy for Future Research Activity |
We will continue the evaluation of immuno-oncology markers in larger series of cases and plan next set of NGS analysis.
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| Causes of Carryover |
Since NGS mutational profile is very expensive, some amount from first year was moved to second year.
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| Remarks |
The following internet sites connect to the research outputs.
Most of the results are in Open Access Journals (DOAJ).
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[Journal Article] Tumor heterogeneity and immune-evasive T follicular cell lymphoma phenotypes at single-cell resolution2023
Author(s)
Suma S, Suehara Y, Fujisawa M, Abe Y, Hattori K, Makishima K, Sakamoto T, Sawa A, Bando H, Kaji D, Sugio T, Kato K, Akashi K, Matsue K, Carreras J, Nakamura N, Suzuki A, Suzuki Y, Ito K, Shiiba H, Chiba S, Sakata-Yanagimoto M
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Journal Title
Leukemia
Volume: 38
Pages: 340～350
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Hepatic niche leads to aggressive natural killer cell leukemia proliferation through transferrin-transferrin receptor 1 axis2023
Author(s)
Kameda K, Yanagiya R, Miyatake Y, Carreras J, Higuchi H, Murayama H, Ishida T, Ito A, Iida S, Fukuhara N, Harigae H, Fujioka Y, Takahashi N, Wada H, Ishida F, Nakazawa H, Ishihara R, Murakami Y, Tagawa H, Matsuura T, Nakagawa S, Iwabuchi S, Hashimoto S, Imadome KI, Nakamura N, Ishizawa K, Kanda Y, Ando K, Kotani A
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Journal Title
Blood Journal
Volume: 142
Pages: 352～364
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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