2016 Fiscal Year Final Research Report
Pioneer the Physical Chemistry of Biological Electron Transfer based on Bacterial Extracellular Electron Transport
| Project/Area Number |
24000010
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| Research Category |
Grant-in-Aid for Specially Promoted Research
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
Chemistry
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| Research Institution | National Institute for Materials Science (2016)
The University of Tokyo (2012-2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Ryuhei 理化学研究所, 環境資源科学研究センター, チームリーダー (10447419)
NAKANISHI Shuji 大阪大学, 太陽エネルギー化学研究センター, 教授 (40333447)
ISHIHARA Kazuhiko 東京大学, 大学院工学系研究科, 教授 (90193341)
TAJIMA Keisuke 東京大学, 大学院工学系研究科, 准教授 (90376484)
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMOTO Akihiro 物質・材料研究機構, エネルギー・環境材料研究拠点, 主任研究員 (70710325)
KAMIYA Kazuhide 大阪大学, 太陽エネルギー化学研究センター, 助教 (50716016)
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| Project Period (FY) |
2012 – 2016
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| Keywords | 細胞外電子移動 / 代謝経路制御 / 微生物エネルギー変換 / 生体電子移動ダイナミクス / 電気化学的制御 / 微生物腐食 / 集団同期能現象 / 光合成細菌 |
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| Outline of Final Research Achievements |
The molecular mechanism of extracellular electron transfer (EET) was clarified through the direct observation of the dynamics, leading to the development of the methodologies for reversible regulation and collective activation of cellular metabolisms. It was also revealed that microorganisms with EET ability are widely distributed in natural environments. Furthermore, we successfully applied the concept of the EET to mammalian cells that do not possess EET ability by developing cytocompatible electron mediators. Based on the systematic understandings of the EET obtained through the present study, novel methodologies and perspectives were provided to various fields, including measurement/regulation of circadian clocks and cancer cells, and proposal of new ecosystem supported by electricity.
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| Free Research Field |
物理化学、電気化学、光化学
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