高次脳領域におけるシナプス伝達制御機構の分子形態学的研究

2015 Fiscal Year Annual Research Report

• Project/Area Number: 24220007
• Research Institution: Hokkaido University
• Principal Investigator: 渡辺 雅彦 北海道大学, 医学(系)研究科(研究院), 教授 (70210945)
• Co-Investigator(Kenkyū-buntansha): 崎村 建司 新潟大学, 脳研究所, 教授 (40162325)
• Project Period (FY): 2012-05-31 – 2017-03-31
• Keywords: シナプス / 情報伝達 / AMPA受容体 / 海馬 / 線条体

Outline of Annual Research Achievements

平成27年度における研究実施により、以下の成果が得られた。
海馬におけるAMPARの標的選択的制御について、シャーファー側枝が標的とする錐体細胞（有孔シナプスと無孔シナプス）、パルブアルブミン陽性介在ニューロン（PVシナプス）、パルブアルブミン陰性ニューロン（nonPVシナプス）のAMPARの発現密度を比較した。その結果、AMPARの発現密度は有孔シナプス＞無孔シナプス、PVシナプス＞nonPVシナプスの順に標的選択性が観察された。この発現密度の違いは、AMPARの調節分子であるTARPg-2とg-8のシナプス発現密度と相関していた。さらに、これらのTARPを欠損するマウスでは、これらのシャーファー側枝シナプスのAMPARの発現密度は均一となり、標的選択性が失われた。以上の結果は、TARPg-2とg-8が海馬CA1におけるAMAPRの標的選択性を決定する分子であることを示し、これらの研究成果はJournal of Neuroscienceに受理された。
黒質線条体ドパミン投射系の伝達様式を追求した所、このドパミンシナプスのシナプス後部にGABA受容体が発現する伝達物資と受容体がミスマッチした異種結合であることを発見した。ドパミンシナプスは，GABAシナプス選択的な接着分子ニューロリギン2が存在し，この分子を培養細胞で発現させると黒質ドパミンニューロンとの接触部位がドパミンシナプスへと分化した。反対に，中型有棘ニューロンでこの分子発現を抑制すると，ドパミンシナプスは減少した。以上の結果は，中型有棘ニューロンはGABAシナプスの接着分子であるニューロリギン2を利用してドパミンシナプス形成を促進し，このニューロンに対するドパミンによる調節の選択性や効率性を賦与していることを示唆する。この研究成果はProceedings of the National Academy of Sciences of the United States of Americaの電子版に2016年3月に公表された。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

当初の研究計画の項目それぞれについて、着実にデータを集積し、論文投稿が受理されている為。

Strategy for Future Research Activity

当初予定した研究計画の残りの部分を着実に実行し推進する。

Research Products

• [Journal Article] The ascending median raphe projections are mainly glutamatergic in the mouse forebrain. (2016)
  • Author(s): Szonyi A, Mayer MI, Cserép C, Takács VT, Watanabe M, Freund TF, Nyiri G
  • Journal Title: Brain Struct Funct, Volume: 221 Pages: 735-751
  • DOI: 10.1007/s00429-014-0935-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phospho-proteomics of the dopamine pathway enables discovery of Rap1 activation as a reward signal in vivo. (2016)
  • Author(s): Nagai T, Nakamuta S, Kuroda K, Nakauchi S, Nishioka T, Takano T, Zhang X, Tsuboi D, Funahashi Y, Nakano T, Yoshimoto J, Kobayashi K, Uchigashima M, Watanabe M, Miura M, Nishi A, Kobayashi K, Yamada K, Amano M, Kaibuchi K
  • Journal Title: Neuron Volume: 89 Pages: 550-565
  • DOI: 10.1016/j.neuron.2015.12.019
  • Peer Reviewed / Open Access
• [Journal Article] Serotonin 5-HT7 receptor in the ventral hippocampus modulates the retrieval of fear memory and stress-induced defecation. (2016)
  • Author(s): Ohmura Y, Yoshida T, Konno K, Minami M, Watanabe M, Yoshioka M
  • Journal Title: Int J Neuropsychopharmacol. Volume: 19 Pages: 1-12
  • DOI: 10.1093/ijnp/pyv131
  • Peer Reviewed / Open Access
• [Journal Article] A quantitative study of neurochemically-defined excitatory interneuron populations in laminae I-III of the mouse spinal cord. (2016)
  • Author(s): Gutierrez-Mecinas M, Furuta T, Watanabe M, Todd A
  • Journal Title: Mol Pain Volume: 12 Pages: 1-18
  • DOI: 10.1177/1744806916629065
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of hormones in olfactory imprinting and homing in chum salmon. (2016)
  • Author(s): Ueda H, Nakamura S, Nakamura T, Inada K, Ookubo T, Furukawa N, Murakami R, Tsuchida S, Zohar Y, Konno K, Watanabe M
  • Journal Title: Sci Rep. Volume: 6 Pages: 21102
  • DOI: 10.1038/srep21102.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Neural FFA3 activation inversely regulates anion secretion evoked by nicotinic ACh receptor activation in rat proximal colon, (2016)
  • Author(s): Kaji I, Akiba Y, Konno K, Watanabe M, Kimura S, Iwanaga T, Kuri A, Iwamoto K, Kuwahara A, Kaunitz JD
  • Journal Title: J Physiol Volume: in press Pages: in press
  • DOI: 10.1113/JP271441
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Emerging Roles of ARHGAP33 in Intracellular Trafficking of TrkB and Pathophysiology of Neuropsychiatric Disorders. (2016)
  • Author(s): Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y , Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M
  • Journal Title: Nat Commun Volume: 7 Pages: 10594
  • DOI: 10.1038/ncomms10594
  • Peer Reviewed
• [Journal Article] Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination. (2016)
  • Author(s): Ichikawa R, Hashimoto K, Miyazaki T, Uchigashima M, Yamasaki M, Aiba A, Kano M, Watanabe M
  • Journal Title: Proc. Natl. Acad. Sci. USA, Volume: 113 Pages: 2282-2287
  • DOI: 10.1038/srep21102
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Membrane palmitoylated protein 2 is a synaptic scaffold protein required for synaptic SK2-containing channel function. (2016)
  • Author(s): Kim G, Luján R, Schwenk J, Kelley M, Aguado C, Watanabe M, Fakler B, Maylie J, Adelman JP
  • Journal Title: eLife Volume: in press Pages: e12637
  • DOI: 10.7554/eLife.12637
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Striatal dopamine synapses are neuroligin-2-mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures. (2016)
  • Author(s): Uchigashima M, Ohtsuka T, Kobayashi K, Watanabe M
  • Journal Title: Proc Natl Acad Sci USA Volume: in press Pages: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] TARP gamma-2 and gamma-8 differentially control biased AMPAR density across Schaffer collateral/commissural synapses in the hippocampal CA1. (2016)
  • Author(s): Yamasaki M, Fukaya M, Yamazaki M, Azechi H, Natsume R, Abe M, Sakimura K, Watanabe M
  • Journal Title: J Neurosci Volume: in press Pages: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Trans-Synaptic Modulation of Kainate Receptor Functions by C1q-like Proteins. (2016)
  • Author(s): Matsuda K, Budisantoso T, Mitakidis N, Sugaya Y, Miura E, Kakegawa K, Yamasaki Yuzaki M
  • Journal Title: Neuron Volume: in press Pages: in press
  • Peer Reviewed
• [Journal Article] Is D-aspartate produced by glutamic-oxaloacetic transaminase -1 like 1(Got1l1), a putative aspartate racemase? (2015)
  • Author(s): Tanaka-Hayashi A, Hayashi S, Inoue R, Ito T, Konno K, Yoshida T, Watanabe M, Yoshimura T, Mori H
  • Journal Title: Amino Acids Volume: 47 Pages: 79-86
  • DOI: 10.1007/s00726-014-1847-3.
  • Peer Reviewed
• [Journal Article] Increased regional gray matter volume in μ-opioid receptor knockout (MOR-KO) mice as determined by MRI voxel-based morphometry. (2015)
  • Author(s): Sasaki K, Sumiyoshi A, Nonaka H, Kasahara Y, Ikeda K, Hall FS, Uhl GR, Watanabe M, Kawashima R, Sora I
  • Journal Title: Br J Pharmacol. Volume: 172 Pages: 654-667
  • DOI: 10.1111/bph.12807.
  • Peer Reviewed
• [Journal Article] Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial temporal lobe epilepsy. (2015)
  • Author(s): Yokoi N, Fukata Y, Kase D, Miyazaki T, Jaegle M, Ohkawa T, Takahashi N, Iwanari H, Mochizuki Y, Hamakubo T, Imoto K, Meijer D, Watanabe M, Fukata M
  • Journal Title: Nat Med, Volume: 21 Pages: 19-26
  • DOI: 10.1038/nm.3759
  • Peer Reviewed
• [Journal Article] Distinct subsynaptic localization of type 1 metabotropic glutamate (mGlu1) receptors at glutamatergic and GABAergic synapses in the rodent cerebellar cortex. (2015)
  • Author(s): Mansouri M, Kasugai Y, Fukazawa Y, Bertaso F, Raynaud F, Perroy J, Fagni L, Kaufmann WA, Watanabe M, Shigemoto R, Ferraguti F
  • Journal Title: Eur J Neurosci, Volume: 41 Pages: 157-167
  • DOI: doi: 10.1111/ejn.12779. Epub 2014 Nov 6.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Regulatory effect of interleukin-4 in the innate inflammatory response to rhodococcus aurantiacus infection in mice. (2015)
  • Author(s): Yimin, Kohanawa M, Zhao S, Li M, Kuge Y, Tamaki N, Watanabe M
  • Journal Title: J Interferon Cytokine Res. Volume: 35 Pages: 222-231
  • DOI: 10.1089/jir.2014.0107.
  • Peer Reviewed
• [Journal Article] Cell type-specific STORM superresolution imaging reveals nanoscale organization of cannabinoid signaling at hippocampal GABAergic synapses. (2015)
  • Author(s): Dudok , Barn L, Ledri M, Szabó SI, Szabadits E, Pintér B, Woodhams SG, Henstridge CM, Balla GY, Nyilas R, Vargav C, Lee S, Matolcsi M, Cervenak J, Kacskovics I, Watanabe M, Sagheddu C, Melis M, Pistis M, Soltesz I, Katona I
  • Journal Title: Nat Neurosci, Volume: 18 Pages: 75-86
  • DOI: 10.1038/nn.3892
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Short-chain fatty acid sensing in rat duodenum. (2015)
  • Author(s): Akiba Y, Inoue T, Kaji I, Higashiyama M, Iwamoto K, Watanabe M, Guth PH, Engel E, Kuwahara A, Kaunitz JD
  • Journal Title: J Physiol, Volume: 593 Pages: 585-599
  • DOI: 10.1113/jphysiol.2014.280792
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Untangling dopamine-adenosine receptor assembly in experimental parkinsonism. (2015)
  • Author(s): Fernández-Dueñas V, Taura JJ, Cottet M, Gómez-Soler M, López-Cano M, Ledent C, Watanabe M, Trinquet E, Pin JP, Luján R, Durroux T, Ciruela F
  • Journal Title: Dis Model Mech, Volume: 8 Pages: 57-63
  • DOI: 10.1242/dmm.018143
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] SCFA transport in rat duodenum. (2015)
  • Author(s): Kaji I, Iwanaga T, Watanabe M, Guth P, Engel E, Kaunitz J, Akiba Y
  • Journal Title: Am J Physiol Gastrointest Liver Physiol, Volume: 308 Pages: G188-197
  • DOI: 10.1152/ajpgi.00298.2014
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Involvement of diacylglycerol kinase Beta in the spine formation at distal dendrites of striatal medium spiny neurons. (2015)
  • Author(s): Hozumi Y, Kakefuda K, Yamasaki M, Watanabe M, Hara H, Goto K
  • Journal Title: Brain Res, Volume: 1594 Pages: 36-45
  • DOI: 10.1016/j.brainres.2014
  • Peer Reviewed
• [Journal Article] Structure-function relationshipsbetween aldolase C/zebrin II expression and complex spike synchrony in the cerebellum. (2015)
  • Author(s): Tsutsumi S, Yamazaki M, Miyazaki M, Watanabe M, Sakimura K, Kano M, Kitamura K
  • Journal Title: J Neurosci, Volume: 35 Pages: 843-852
  • DOI: 10.1523/JNEUROSCI.2170-14.2015.
  • Peer Reviewed
• [Journal Article] Developmental tightening of cerebellar cortical synaptic influx-release coupling. (2015)
  • Author(s): Baur D, Bornschein G, Althof D, Watanabe M, Kulik A, Eilers J, Schmidt H
  • Journal Title: J Neurosci, Volume: 35 Pages: 1858-1871
  • DOI: 10.1523/JNEUROSCI.2900-14.2015.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum. (2015)
  • Author(s): Kakegawa W, Mitakidis N, Miura E, Abe M, Matsuda K, Takeo YH, Kohda K, Motohashi J, Takahashi A, Nagao S, Muramatsu S, Watanabe M, Sakimura K, Aricescu AR, Yuzaki M
  • Journal Title: Neuron Volume: 85 Pages: 316-329
  • DOI: 10.1016/j.neuron.2014.12.020.
  • Peer Reviewed
• [Journal Article] VGluT3-expressing CCK-positive basket cells construct invaginating synapses enriched with endocannabinoid signaling proteins in particular cortical and cortex-like amygdaloid regions of mouse brains. (2015)
  • Author(s): Omiya Y, Uchigashima M, Konno K, Yamasaki M, Miyazaki T, Yoshida T, Kusumi I, Watanabe M
  • Journal Title: J Neurosci, Volume: 35 Pages: 4215-4225
  • DOI: 10.1523/JNEUROSCI.4681-14.2015.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Inhibitory interneurons that express GFP in the PrP-GFP mouse spinal cord are morphologically heterogeneous, innervated by several classes of primary afferent and include lamina I projection neurons among their postsynaptic targets. (2015)
  • Author(s): Ganley R, Iwagaki N, del Rio P, Baseer N, Dickie AC, Polgár E, Watanabe M, Abraira VE, Ginty DD, Riddell J, Todd AJ
  • Journal Title: J Neurosci, Volume: 35 Pages: 7626-7642
  • DOI: 10.1523/JNEUROSCI.4681-14.2015.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cellular and subcellular localization of cholecystokinin (CCK)-1 receptors in the pancreas, gallbladder, and stomach of mice. (2015)
  • Author(s): Konno K, Takahashi-Iwanaga H, Uchigashima M, Miyasaka K, Funakoshi A, Watanabe M, Iwanaga T
  • Journal Title: Histochem Cell Biol. Volume: 143 Pages: 301-312
  • DOI: 10.1007/s00418-014-1281-3.
  • Peer Reviewed
• [Journal Article] Weeding out bad waves: towards selective cannabinoid circuit control. (2015)
  • Author(s): Alger B, Kano M, Lee SH, Lovinger D, Ohno-Shosaku T, Watanabe M
  • Journal Title: Nat Rev Neurosci, Volume: 16 Pages: 264-272
  • DOI: 10.1038/nrn3937
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Repeated fluvoxamine treatment recovers juvenile stress-induced morphological changes and depressive-likebehavior in rats. (2015)
  • Author(s): Lyttle K, Ohmura Y, Konno K, Yoshida T, Izumi T, Watanabe M, Yoshioka M
  • Journal Title: Brain Res, Volume: 1616 Pages: 88-100
  • DOI: 10.1016/j.brainres.2015.04.058.
  • Peer Reviewed
• [Journal Article] Production of monoclonal antibodies against GPCR using cell-free synthesized GPCR antigen and biotinylated liposome-based interaction assay. (2015)
  • Author(s): Takeda H, Ogasawara T, Ozawa T, Muraguchi A, Jih PJ, Morishita R, Uchigashima M, Watanabe M, Fujimoto T, Iwasaki T, Endo Y, Sawasaki T
  • Journal Title: Sci Rep, Volume: 5 Pages: 11333
  • DOI: 10.1038/srep11333.
  • Peer Reviewed
• [Journal Article] The organisation of spinoparabrachial neurons in the mouse. (2015)
  • Author(s): Cameron D, Polgár E,Gutierrez-Mecinas M, Gomez-Lima M, Watanabe M, Todd AJ,
  • Journal Title: Pain Volume: 156 Pages: 2061-2071
  • DOI: 10.1097/j.pain.0000000000000270.
  • Peer Reviewed
• [Journal Article] Multiple forms of endocannabinoid and endovanilloid signaling regulate the tonic control of GABA release. (2015)
  • Author(s): Lee SH, Marco L, Tóth B, Marchionni I, Henstridge CM, Dudok B, Kenesei K, Barna L, Szabó SI, Renkecz T, Oberoi MK, Watanabe M, Limoli C, Horvai G, Soltesz I, Katona I
  • Journal Title: J Neurosci Volume: 35 Pages: 10039-10057
  • DOI: 10.1523/JNEUROSCI.4112-14.2015.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cholinergic afferent stimulation induces axonal function plasticity in adult hippocampal granule cells. (2015)
  • Author(s): Martinello K, Huang Z, Lujan R, Tran B, Watanabe M, Cooper EC, Brown DA, Shah MM
  • Journal Title: Neuron Volume: 85 Pages: 346-363
  • DOI: 10.1016/j.neuron.2014.12.030
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Immunohistochemical localization of GLUT3, MCT1, and MCT2 in the testes of mice and rats: the use of different energy sources in spermatogenesis. (2015)
  • Author(s): Kishimoto A, Ishiguro-Oonuma T, Takahashi R, Maekawa M, Toshimori K, Watanabe M, Iwanaga T
  • Journal Title: Biomed Res Volume: 36 Pages: 225-234
  • DOI: 10.2220/biomedres.36.225.
  • Peer Reviewed
• [Journal Article] A CDC42EP4/septin-based perisynaptic glial scaffold that facilitates glutamate clearance. (2015)
  • Author(s): Ageta-Ishihara N, Yamazaki M, Konno K, Nakayama H, Abe M, Hashimoto K, Nishioka T, Kaibuchi K, Hattori S, Miyakawa T, Tanaka T, Huda F, Hirai H, Hashimoto K, Watanabe M, Sakimura K, Kinoshita M
  • Journal Title: Nat Commun, Volume: 6 Pages: 10090
  • DOI: 10.2220/biomedres.36.225.
  • Peer Reviewed
• [Journal Article] Inhibitory and excitatory axon terminals share a common nano-architecture of their Cav2.1 (P/Q-type) Ca2+ channels. (2015)
  • Author(s): Althof D, Baehrens D, Watanabe M, Suzuki N, Fakler BP, Kulik A
  • Journal Title: Front Cell Neurosci. Volume: 9 Pages: 315
  • DOI: 10.3389/fncel.2015.00315
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Novel splice variants in the 5’UTR of Gtf2i expressed in the rat brain: alternative 5’UTRs and differential expression in the neuronal dendrites. (2015)
  • Author(s): Shirai Y, Watanabe M, Sakagami H, Suzuki T
  • Journal Title: J Neurochem Volume: 134 Pages: 578-589
  • DOI: 10.1111/jnc.13136
  • Peer Reviewed
• [Journal Article] Expression and localization of the diacylglycerol kinase family and phosphoinositide signaling molecules in the adrenal gland. (2015)
  • Author(s): Hozumi Y, Akimoto R, Suzuki A, Otani K, Watanabe M, and Goto K
  • Journal Title: Cell Tissue Res Volume: 362 Pages: 295-305
  • DOI: 10.1007/s00441-015-2199-3
  • Peer Reviewed
• [Journal Article] A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia. (2015)
  • Author(s): Morino H, Matsuda Y, Muguruma K, Miyamoto R, Ohsawa R, Ohtake T, Otobe R, Watanabe M, Maruyama H, Hashimoto K, Kawakami H:
  • Journal Title: Mol Brain Volume: 8 Pages: 89,
  • DOI: 10.1186/s13041-015-0180-4.
  • Peer Reviewed
• [Presentation] 小脳登上線維と抑制性細胞間における非シナプス性結合と選択的分子発現 (2016)
  • Author(s): 山崎美和子、深谷昌弘、宋暁紅、内ヶ島基政、宮崎太輔、今野幸太郎、渡辺雅彦
  • Organizer: 第121回日本解剖学会総会・全国学術集会
  • Place of Presentation: ビッグパレットふくしま・郡山
  • Year and Date: 2016-03-28 – 2016-03-30
• [Presentation] Neuroanatomical properties of cerebellar interneuron Lugaro cells using with GFP–expressing transgenic mice line (2016)
  • Author(s): Taisuke Miyazaki, Kenji F. Tanaka, Masahiko Watanabe
  • Organizer: 第121回日本解剖学会総会・全国学術集会
  • Place of Presentation: ビッグパレットふくしま・郡山
  • Year and Date: 2016-03-28 – 2016-03-30
• [Presentation] マウス脳におけるグルタミン酸受容体GluD familyの発現特性 (2016)
  • Author(s): 今野幸太郎、渡辺雅彦
  • Organizer: 第121回日本解剖学会総会・全国学術集会
  • Place of Presentation: ビッグパレットふくしま・郡山
  • Year and Date: 2016-03-28 – 2016-03-30
• [Presentation] GluD1とCbln1は外側膝状体における二丘傍核由来のグルタミン酸作動性/コリン作動性神経終末とのシナプス形成に必須である (2016)
  • Author(s): 山田真司、今野幸太郎、西川晃司、崎村建司、渡辺雅彦
  • Organizer: 第121回日本解剖学会総会・全国学術集会
  • Place of Presentation: ビッグパレットふくしま・郡山
  • Year and Date: 2016-03-28 – 2016-03-30
• [Presentation] Morphological characteristics of cerebellar interneuron Lugaro cells using with GFP–expressing transgenic mice line (2015)
  • Author(s): Taisuke Miyazaki, Kenji F. Tanaka, Masahiko Watanabe
  • Organizer: Neuroscience 2015
  • Place of Presentation: Chicago,US
  • Year and Date: 2015-10-17 – 2015-10-21
  • Int'l Joint Research
• [Presentation] Molecular determinants underlying heterogeneity in AMPAR content across CA1 Schaffer collateral synapses (2015)
  • Author(s): Yamasaki M, Fukaya M, Yamazaki M, Azechi H, Natsume R, Abe M, Sakimura K, Watanabe M
  • Organizer: Neuroscience 2015
  • Place of Presentation: Chicago,US
  • Year and Date: 2015-10-17 – 2015-10-21
  • Int'l Joint Research
• [Presentation] Striatal dopamine synapses are neuroligin-2-mediated heterologous contacts between dopaminergic presynapse and GABAergic postsynapse (2015)
  • Author(s): Motokazu Uchigashima, Masahiko Watanabe
  • Organizer: Neuroscience 2015
  • Place of Presentation: Chicago,US
  • Year and Date: 2015-10-17 – 2015-10-21
  • Int'l Joint Research
• [Presentation] プルキンエ細胞に発現するカルシニューリンCNB1サブユニットは小脳の興奮性および抑制性シナプス回路形成に重要である (2015)
  • Author(s): 宮崎 太輔, 崎村 建司, 渡辺 雅彦
  • Organizer: 第61回東北・北海道連合支部学術集会
  • Place of Presentation: 盛岡市観光文化交流センター・盛岡
  • Year and Date: 2015-08-29 – 2015-08-30
• [Presentation] プルキンエ細胞に発現するCNB1は小脳の興奮性および抑制性シナプス回路形成に重要である (2015)
  • Author(s): Taisuke Miyazaki, Kenji Sakimura , Masahiko Watanabe
  • Organizer: 第３８回日本神経科学大会
  • Place of Presentation: 神戸国際会議場・神戸市
  • Year and Date: 2015-07-28 – 2015-07-31
• [Presentation] NMDA受容体サブユニットNR2BとNR2Dは体性感覚系の興奮性・抑制性回路に選択的に発 現し、回路発達に相反的な作用を及ぼすOpposing role of NMDA receptor GluN2B and GluN2D in somatosensory development and maturation (2015)
  • Author(s): Yamasaki M, Okada R, Takasaki C, Toki S, Fukaya M, Natsume R, Sakimura K, Mishina M, Shirakawa T, Watanabe M
  • Organizer: 第３８回日本神経科学大会
  • Place of Presentation: 神戸国際会議場・神戸市
  • Year and Date: 2015-07-28 – 2015-07-31
• [Presentation] 皮質系構造においてVGluT3/CCK発現バスケット細胞は内因性カンナビノイドシグナル伝達関連分子を豊富に備えた貫入型シナプスを形成する (2015)
  • Author(s): Motokazu Uchigashima , Masahiko Watanabe
  • Organizer: 第３８回日本神経科学大会
  • Place of Presentation: 神戸国際会議場・神戸市
  • Year and Date: 2015-07-28 – 2015-07-31
• [Presentation] Distinct expression of CCK1 receptors along vagal affrerent and efferent pathways and their anatomical relationship with neuronal and humoral sources of CCK in adult mice (2015)
  • Author(s): Kohtarou Konno, Toshihiko Iwanaga, Masahiko Watanabe
  • Organizer: 第３８回日本神経科学大会
  • Place of Presentation: 神戸国際会議場・神戸市
  • Year and Date: 2015-07-28 – 2015-07-31