2014 Fiscal Year Final Research Report
Global anallysis of genetic and epigenetic alterations during inflammation-associated gastrointestinal cancer development, and elucidation of its mechanism
Project/Area Number |
24229005
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Research Category |
Grant-in-Aid for Scientific Research (S)
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Allocation Type | Single-year Grants |
Research Field |
Gastroenterology
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Research Institution | Kyoto University |
Principal Investigator |
CHIBA Tsutomu 京都大学, 医学(系)研究科(研究院), 教授 (30188487)
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Co-Investigator(Kenkyū-buntansha) |
MARUSAWA Hiroyuki 京都大学, 医学研究科, 講師 (80324630)
WATANABE Tomohiro 京都大学, 医学研究科, 准教授 (40444468)
USHIJIMA Toshikazu 独立行政法人国立がん研究センター, 研究所 (90232818)
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Project Period (FY) |
2012-05-31 – 2015-03-31
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Keywords | AID / 炎症発癌 / 癌幹細胞 / 組織幹細胞 / エピゲノム / 遺伝子変異 |
Outline of Final Research Achievements |
Infection and/or inflammation play important roles in the development of various cancers in digestive organs. We have previously demonstrated that activation-induced cytidine deaminase (AID), a DNA editing enzyme, is involved in inflammation-associated carcinogenesis through induction of various mutations. In the present study, by using ultra-deep sequencer we serially analyzed genetic and epigenetic changes during cancer development with the background of inflammation in both human and mice. As a result, we demonstrated that AID has crucial roles in the induction of not only genetic but also epigenetic changes during inflammation-induced carcinogenesis.
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Free Research Field |
消化器病学、消化器癌発症の機序、新しい癌治療の開発
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