Self and non-self in mouse-rat chimera

2014 Fiscal Year Final Research Report

• Project/Area Number: 24240066
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory animal science
• Research Institution: Osaka University
• Principal Investigator: OKABE Masaru 大阪大学, 微生物病研究所, 特任研究員(常勤) (30089875)
• Co-Investigator(Kenkyū-buntansha): ISOTNI Ayako 大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤) (20444523)
• Co-Investigator(Renkei-kenkyūsha): IKAWA Masahito 大阪大学, 微生物病研究所, 教授 (20304066) ; YAMAGATA Kazuo 大阪大学, 微生物病研究所, 特任准教授(常勤) (10361312)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 免疫 / マウス・ラットキメラ / 自己・非自己

Outline of Final Research Achievements

A special interaction is said to be established during pregnancy between the maternal immune system and fetal cells to allow the survival and the normal growth of the fetus. A local immunosuppression is considered to be an important feature of a pregnancy. However, when we used heavily immunodeficiency mice for the recipient of rat embryos, the duration until the miscarriage was the same with wild-type mice. This was also true when the mouse-rat chimera was used for the recipient mothers. Moreover, producing embryos with mouse placenta and rat fetus also revealed that the immunity was not the first cause of a zenogenetic abortion.

Free Research Field

動物実験学