2014 Fiscal Year Final Research Report
Strength and Stress Characterization based on Mechanical Interaction between Mineral and Collagen Components in Bone tissue
Project/Area Number |
24240068
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biomedical engineering/Biological material science
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Research Institution | Hokkaido University |
Principal Investigator |
TADANO Shigeru 北海道大学, 工学(系)研究科(研究院), 名誉教授 (50175444)
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Co-Investigator(Kenkyū-buntansha) |
SASAKI Naoki 北海道大学, 大学院先端生命科学研究院, 教授 (40142202)
FUJISAKI Kazuhiro 弘前大学, 大学院理工学研究科, 准教授 (90435678)
YOKOTA Hideo 理化学研究所, その他, 研究員 (00261206)
ITO Manabu 北海道大学, 大学院医学研究科, 特任教授 (00271677)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | バイオメカニクス / 生体骨組織 / 応力検出 / X線回折 / ハイドロキシアパタイト / 結晶配向性 / コラーゲン |
Outline of Final Research Achievements |
Bone shows a hierarchical structure from a nano scale of hydroxyapatite crystal and collagen molecular to a macro scale of cortical and cancellous bone. This work proposed a new method of detecting stress of tissue level using the information of HAp crystal deformation and collagen molecular deformation. X-ray diffraction experimental procedure and Raman spectroscopy method were developed to measure the characteristics of hierarchical structure. Some structural parameters were introduced to represent these characteristics. Also, the XRD method was applied to detect residual stress in bone, and the stress was observed at various regions in animal extremities.
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Free Research Field |
バイオメカニクス、人間医工学
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