Determinants of Intraindividual variability in energy metabolism and the relationship with obesity

2015 Fiscal Year Final Research Report

• Project/Area Number: 24240092
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: National Institutes of Biomedical Innovation, Health and Nutrition (2015); National Institute of Health and Nutrition
• Principal Investigator: Tanaka Shigeho 国立研究開発法人医薬基盤・健康・栄養研究所, 国立健康・栄養研究所 基礎栄養研究部, 部長 (50251426)
• Co-Investigator(Kenkyū-buntansha): TOKUYAMA Kumpei 筑波大学, 体育系, 教授 (00207565) ; TAKATA KAZUKO 国立研究開発法人医薬基盤・健康・栄養研究所, 国立健康・栄養研究所 栄養教育研究部, 室長 (80202951) ; TANAKA CHIAKI 桜美林大学, 総合科学系, 准教授 (40369616) ; MATSUSHITA MAMI 天使大学, 看護栄養学部, 助教 (60517316)
• Research Collaborator: SAITO MASAYUKI 北海道大学, 名誉教授 (80036441)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: エネルギー代謝 / 身体活動 / 個人内変動 / 褐色脂肪

Outline of Final Research Achievements

We evaluated intraindividual variability in energy metabolism and physical activity and investigated the relationship with brown adipose tissue activity and obesity. As a result, brown adipose tissue activity contributed to seasonal variation in cold-induced thermogenesis, and interindividual variability of diet-induced thermogenesis and fat oxidation. Moreover, there was a significant correlation between cold-induced thermogenesis and total energy expenditure only in winter. Percentage of energy as fat at dinner was correlated with substrate oxidation during sleep and quantity and quality of sleep. Exercise in the fasting state in the morning was associated with more 24 hour fat oxidation. Both boys and girls in elementary school were less active in summer vacation than in May (school year), although the changes in body weight and in physical activity were not associated.

Free Research Field

応用健康科学