Effects of stresses via CNS on fish energy metabolisms and immunological systems

2014 Fiscal Year Final Research Report

• Project/Area Number: 24248037
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Fisheries chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: USHIO Hideki 東京大学, 農学生命科学研究科, 教授 (50251682)
• Co-Investigator(Kenkyū-buntansha): HIRONO Ikuo 東京海洋大学, 大学院 (00270926) ; KONDO Hidehiro 東京海洋大学, 大学院 (20314635) ; NAGASAKA Reiko 東京海洋大学, 大学院 (90444132) ; KANEKO Gen 東京大学, 大学院 (30466809)
• Project Period (FY): 2012-10-31 – 2015-03-31
• Keywords: 水産業 / シグナル伝達 / 発現制御 / ストレス

Outline of Final Research Achievements

Evaluation methods of fish stress responses via central nervous system including visual stress, overcrowding stress, etc. were developed. Proteofragmentome analysis using NanoLC-MS/MS developed in this research suggested that proteolyses related to autophagy, proteasome system, and apoptosis occur in normal fish muscle tissue, and that the proteolyses are upregulated by the stresses. Immunological responses against the stresses were partly different among fish species. gamma Oryzanol is a stress-suppressor.

Free Research Field

水産化学