2014 Fiscal Year Final Research Report
Novel immune regulation by PirB-related multiple ligands
| Project/Area Number |
24249016
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
INUI Masanori 東北大学, 加齢医学研究所, 講師 (80443985)
ENDO Shota 東北大学, 加齢医学研究所, 助教 (70466580)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 免疫制御 / 免疫抑制 / 免疫受容体 / 自然免疫 / アレルギー / 自己免疫疾患 / B細胞分化 / 抗体産生 |
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| Outline of Final Research Achievements |
We have attempted to elucidate a whole spectrum of PirB (or human LILRB)-mediated immune regulation through its binding to the multiple ligands such as Nogo and MHC class I molecules, and to develop novel therapeutic strategies against immune disorders such as allergy and autoimmune diseases. We have found that Nogo is preferentially localized to endoplasmic reticulum and regulates TLR9-mediated immune activation via interacting with GRAMD4 but not PirB. Also, we have characterized a human novel B-lineage cell subset, CD43+ B cells, as an intermittent pre-plasmablastic population but not human B1-like cells, being positioned between memory B cells and plasmablasts in terms of its surface LILRB expression, antibody and cytokine secretion, and transcriptional factor expression profiles.
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| Free Research Field |
医歯薬学（免疫学）
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