2014 Fiscal Year Final Research Report
| Project/Area Number |
24249021
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
|
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| Research Institution | University of Tsukuba |
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Principal Investigator |
AKIRA Shibuya 筑波大学, 医学医療系, 教授 (80216027)
|
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 免疫グロブリン様受容体 / 炎症 / 自己免疫病 / 発がん / 感染 |
|---|
| Outline of Final Research Achievements |
The mechanisms of immune responses in infectious diseases, autoimmune diseases, inflammatory bowel diseases and allergy are incompletely understood. It is essentially required for the overcome of these intractable diseases to clarify the mechanisms. The aim of this study is to clarify the role of the immunoglobulin-like receptors that we first identified in the pathogenesis of these intractable diseases. We demonstrated that MAIR-I regulates mast cell activation and is involved in the pathogenesis of sepsis in mice. We also demonstrated that MAIR-II regulates the transmigration of inflammatory monocytes into the site of infection and is involved in the peritonitis in mice.
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| Free Research Field |
免疫学
|
