2014 Fiscal Year Annual Research Report
| Project/Area Number |
24249046
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| Research Institution | Keio University |
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Principal Investigator |
日比 紀文 慶應義塾大学, 医学部, 名誉教授 (50129623)
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| Co-Investigator(Kenkyū-buntansha) |
緒方 晴彦 慶應義塾大学, 医学部, 教授 (30177117)
金井 隆典 慶應義塾大学, 医学部, 教授 (40245478)
佐藤 俊朗 慶應義塾大学, 医学部, 特任准教授 (70365245)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 下部消化管 / 潰瘍性大腸炎 |
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| Outline of Annual Research Achievements |
潰瘍性大腸炎は主に若年者に発症する原因不明の慢性炎症性疾患である．本疾患患者数の増加と罹患患者の高齢化に伴い，潰瘍性大腸炎合併大腸癌（CAC）が増加傾向にあり，問題となっている．我々はCAC症例により腫瘍サンプルを採取し,オルガノイドの樹立,そのCACオルガノイドの統合的な解析を行った.CACでは通常型のがんに比べ,低頻度のAPC変異と高頻度のTP53変異を認めた.これによりCACオルガノイドの樹立とその分子遺伝学的解析データが統合され,今後のCACに対する基礎研究ならびにトレンスレーショナルリサーチの進展に極めて有用である成果が得られたと考える.
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| Research Progress Status |
26年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
26年度が最終年度であるため、記入しない。
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Research Products
(47 results)
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[Journal Article] Macrophages and Dendritic Cells Emerge in the Liver during Intestinal Inflammation and Predispose the Liver to Inflammation.2014
Author(s)
Mikami Y, Mizuno S, Nakamoto N, Hayashi A, Sujino T, Sato T, Kamada N, Matsuoka K, Hisamatsu T, Ebinuma H, Hibi T, Yoshimura A, Kanai T.
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Journal Title
PLoS One
Volume: 9(1)
Pages: e84619
DOI
Peer Reviewed
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[Journal Article] Use of capsule endoscopy in patients with Crohn's disease in Japan: a multicenter survey.2014
Author(s)
Esaki M, Matsumoto T, Watanabe K, Arakawa T, Naito Y, Matsuura M, Nakase H, Hibi T, Matsumoto T, Nouda S, Higuchi K, Ohmiya N, Goto H, Kurokawa S, Motoya S, Watanabe M.
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Journal Title
J Gastroenterol Hepatol
Volume: 29(1)
Pages: 96-101
DOI
Peer Reviewed
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[Journal Article] Continuous low-dose irradiation by l-125 seeds induces apoptosis of gastric cancer cells regardless of histological origin.2014
Author(s)
Takabayashi K, Kashiwagi K, Kawata T, Sato T, Matsuoka K, Hisamatsu T, Takaishi H, Hibi T, Ogata H, Yahagi N, Kitagawa Y, Shigematsu N, Kanai T.
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Journal Title
Cancer Biol Ther
Volume: 15(1)
Pages: 81-8
DOI
Peer Reviewed
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[Journal Article] The 2nd edition of consensus statements for the diagnosis and management of intestinal Behcet's disease: indication of anti-TNFα monoclonal antibodies.2014
Author(s)
Hisamatsu T, Ueno F, Matsumoto T, Kobayashi K, Koganei K, Kunisaki R, Hirai F, Nagahori M, Matsushita M, Kobayashi K, Kishimoto M, Takeno M, Tanaka M, Inoue N, Hibi T.
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Journal Title
J Gastroenterol
Volume: 49(1)
Pages: 156-62
DOI
Peer Reviewed
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[Journal Article] Free cholesterol accumulation in hepatic stellate cells: mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice.2014
Author(s)
Tomita K, Teratani T, Suzuki T, Shimizu M, Sato H, Narimatsu K, Okada Y, Kurihara C, Irie R, Yokoyama H, Shimamura K, Usui S, Ebinuma H, Saito H, Watanabe C, Komoto S, Kawaguchi A, Nagao S, Sugiyama K, Hokari R, Kanai T, Miura S, Hibi T.
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Journal Title
Hepatology
Volume: 59(1)
Pages: 154-69
DOI
Peer Reviewed
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[Journal Article] Subcutaneous Golimumab Induces Clinical Response and Remission in Patients With Moderate to Severe Ulcerative Colitis.2014
Author(s)
Sandborn WJ, Feagan BG, Marano C, Zhang H, Strauss R, Johanns J, Adedokun OJ, Guzzo C, Colombel JF, Reinisch W, Gibson PR, Collins J, Jarnerot G, Hibi T, Rutgeerts P; PURSUIT-SC Study Group.
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Journal Title
Gastroenterology
Volume: 146(1)
Pages: 85-95
DOI
Peer Reviewed
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[Journal Article] C-reactive protein is an indicator of serum infliximab level in predicting loss of response in patients with Crohn's disease.2014
Author(s)
Hibi T,Sakuraba A,Watanabe M,Motoya S,Ito H, Sato N,Yoshinari T,Motegi K,Kinouchi Y,Takazoe M,Suzuki Y,Matsumoto T,Kawakami K,Matsumoto T,Hirata I,Tanaka S,Ashida T,Matsui T.
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Journal Title
J Gastroenterol
Volume: 49
Pages: 254-62
DOI
Peer Reviewed
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[Journal Article] Efficacy and safety of adalimumab in Japanese patients with moderately to severely active ulcerative colitis.2014
Author(s)
Suzuki Y,Motoya S,Hanai H,Matsumoto T,Hibi T,Robinson AM,Mostafa NM,Chao J,Arora V,Camez A,Thakkar RB,Watanabe M.
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Journal Title
J Gastroenterol
Volume: 49
Pages: 283-94
DOI
Peer Reviewed
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[Journal Article] A large-scale,prospective,observational study of leukocytapheresis for ulcerative colitis:treatment outcomes of 847 patients in clinical practice2014
Author(s)
Yokoyama Y, Matsuoka K, Kobayashi T, Sawada K, Fujiyoshi T, Ando T, Ohnishi Y, Ishida T, Oka M, Yamada M, Nakamura T, Ino T, Numata T, Aoki H, Sakou J, Kusada M, Maekawa T, Hibi T.
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Journal Title
Journal of Crohn's and Colitis
Volume: 8
Pages: 981-91
DOI
Peer Reviewed
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[Journal Article] Modified bowel preparation regimen for use in second-generation colon capsule endoscopy in patients with ulcerative colitis2014
Author(s)
Usui S, Hosoe N, Matsuoka K, Kobayashi T, Nakano M, Naganuma M, Ishibashi Y, Kimura K, Yoneno K, Kashiwagi K, Hisamatsu T, Inoue N, Serizawa H, Hibi T, Ogata H, Kanai T.
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Journal Title
Digestive Endoscopy
Volume: 26(5)
Pages: 665-72
DOI
Peer Reviewed
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[Journal Article] Surveillance using trimodal imaging endoscopy after endoscopic submucosal dissection for superficial gastric neoplasia.2014
Author(s)
Imaeda H, Hosoe N, Kashiwagi K, Ida Y, Nakamura R, Suzuki H, Saito Y, Yahagi N, Iwao Y, Kitagawa Y, Hibi T, Ogata H, Kanai T.
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Journal Title
World Journal of Gastroenterology
Volume: 20(43)
Pages: 16311-7
DOI
Peer Reviewed
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[Presentation] Twice-daily budesonide rectal foam induces complete mucosal healing in Japanese patients with mild to moderate Ulcerative Colitis : Results of multicentre, randomised, double-blind,placebo-controlled trial2015
Author(s)
N.Aoyama,Y.Suzuki,H.Nishino,K.Kobayashi,F.Hirai,K.Watanabe,M,Naganuma,T.Hibi
Organizer
10th Congress of ECCO
Place of Presentation
バルセロナ（スペイン）
Year and Date
2015-02-18 – 2015-02-21
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[Presentation] Infliximab therapy for Japanese patients with Ulcerative Colitis : Efficacy,safety,and association between serum infliximab levels and early respnse in a randomized, double-blind,placebo-controlled study2015
Author(s)
Y.Suzuki,S.Motoya,F.Hirai,H.Ogata,H.Ito,N.Sato,K.Ozaki,M.Watanabe,T.Hibi
Organizer
10th Congress of ECCO
Place of Presentation
バルセロナ（スペイン）
Year and Date
2015-02-18 – 2015-02-21
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[Presentation] AJM300, an Oral α4 Integrin Antagonist, for Active Ulcerative Colitis: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2A Study2014
Author(s)
Mamoru Watanabe, Naoki Yoshimura, Satoshi Motoya, Keiichi Tominaga, Ryuichi Iwakiri, Kenji Watanabe, Toshifumi Hibi
Organizer
DDW
Place of Presentation
神戸
Year and Date
2014-05-03 – 2014-05-06
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[Presentation] Efficacy and Safety of Rikkunshito, a Japanese Herbal Medicine, on the Treatment of Functional Dyspepsia: A Multi-Center, Double-Blind, Randomized, Placebo-Controlled Study2014
Author(s)
Hidekazu Suzuki, Juntaro Matsuzaki, Yasushi Fukushima, Fumio Suzaki, Kunio Kasugai, Toshihiro Nishizawa, Yuji Naito, Toshihiko Hayakawa, Takeshi Kamiya, Takashi Ando, Hideo Yoshida, Yoshifumi Tokura, Hiroshi Nagata, Masao Kobayakawa, Mikiji Mori, Kimihiko Kato, Hiroshi Hosoda, Toru Takebayashi, Soichiro Miura, Naomi
Organizer
DDW
Place of Presentation
神戸
Year and Date
2014-05-03 – 2014-05-06
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[Presentation] Percutaneous Endoscopic Gastrostomy Under Steady Pressure Automatically Controlled Endoscopy (SPACE)2014
Author(s)
Hiroyuki Imaeda, Kiyokazu Nakajima, Naoki Hosoe, Masanori Nakahara, Shinichiro Zushi, Motohiko Kato, Kazuhiro Kashiwagi, Yasushi Matsumoto, Rieko Nakamura, Noihiro Wada, Masahiko Tsujii, Naohisa Yahagi, Toshifumi Hibi, Tetsuo Takahara.
Organizer
DDW
Place of Presentation
神戸
Year and Date
2014-05-03 – 2014-05-06
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