Pre-clinical application of an innovative therapy, "BioKnife", to malignant pleural mesothelioma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24249071
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Kyushu University
• Principal Investigator: MAEHARA Yoshihiko 九州大学, 医学(系)研究科(研究院), 教授 (80165662)
• Co-Investigator(Kenkyū-buntansha): YONEMITSU Yoshikazu 九州大学, 薬学研究院, 教授 (40315065) ; IKEDA Tetsuo 九州大学, 大学病院, 准教授 (60585701) ; OKI Eiji 九州大学, 医学研究院, 准教授 (70380392) ; SAEKI Hiroshi 九州大学, 大学病院, 講師 (80325448) ; OKAMOTO Tatsuro 九州大学, 大学病院, 助教 (80568626)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 悪性胸膜中皮腫 / 遺伝子治療

Outline of Final Research Achievements

Since malignant pleural mesothelioma (MPM) easily spreads throughout the intrathoracic pleural cavity, and mostly shows resistance to the ordinary chemotherapy, it still one of the most aggressive disease among neoplastic diseases. Alost all MPM cells have been shown to express urokinase-type plasminogen activator receptor (uPAR). Recently, we demonstrated the potential of our new and powerful recombinant Sendai virus (rSeV), which shows uPAR-specific cell-to-cell fusion activity (named “BioKnife”). In the present study, we examined the tumor cell-killing mechanism via BioKnife more precisely to obtain the most sufficient effect on treating MPM that is characterized by frequent uPAR expression in a clinical setting.

Free Research Field

呼吸器外科