2014 Fiscal Year Annual Research Report
ヒト病態類似モデルマウス作成を介した妊娠高血圧症候群の予知・予防・治療戦略開発
Project/Area Number |
24249080
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Research Institution | Osaka University |
Principal Investigator |
木村 正 大阪大学, 医学(系)研究科(研究院), 教授 (90240845)
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Co-Investigator(Kenkyū-buntansha) |
澤田 健二郎 大阪大学, 医学(系)研究科(研究院), 講師 (00452392)
冨松 拓治 大阪大学, 医学(系)研究科(研究院), 講師 (30346209)
金川 武司 大阪大学, 医学(系)研究科(研究院), 助教 (40346218)
味村 和哉 大阪大学, 医学(系)研究科(研究院), 助教 (50437422)
中村 仁美 大阪大学, 医学(系)研究科(研究院), 助教 (80467571)
熊澤 惠一 大阪大学, 医学部附属病院, 助教 (90444546)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | 妊娠高血圧症候群 |
Outline of Annual Research Achievements |
妊娠高血圧症候群および子癇は全妊娠の5〜7%に発生し、日本を含む先進国ではしばしば重篤な母体、胎児への罹患と集中管理を必要とする。低医療資源国では重症化により未だに最大の母体死亡の原因である。平成26年度は、下記の2つを主に行った。 1)妊娠初期発症予測因子の探索: 妊娠高血圧症候群の重症化マウスを用いて、このマウスの血液中の血管新生因子及び、抗血管新生因子の濃度、胎児の大きさ、尿蛋白など血圧上昇以外のの評価を行った。さらに候補治療薬を投与し、その効果、副作用を評価した上で、今後学会発表、論文投稿などを行う予定である。 2)既存薬ライブラリーのスクリーニング:前年度より検討したPIGF産生能の優れた 薬剤を一つにまで選別を行い、それを論文報告を行い、掲載された(Reprod Sci. 2015 Mar 2. pii: 1933719115574340)。
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Research Progress Status |
26年度が最終年度であるため、記入しない。
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Strategy for Future Research Activity |
26年度が最終年度であるため、記入しない。
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[Journal Article] Perioperative venous thromboembolism in patients with gynecological malignancies: a lesson from four years of recent clinical experience2014
Author(s)
Morimoto, A. Ueda, Y. Yokoi, T. Tokizawa, Y. Yoshino, K. Fujita, M. Toshihiro Kimura Kobayashi, E. Matsuzaki, S. Egawa-Takata, T. Sawada, K. Tsutsui, T. Kimura, T.
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Journal Title
Anticancer Res
Volume: 34
Pages: 3589-3595
Peer Reviewed
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[Journal Article] Combination treatment with trabectedin and irinotecan or topotecan has synergistic effects against ovarian clear cell carcinoma cells2014
Author(s)
Kawano, M. Mabuchi, S. Kishimoto, T. Hisamatsu, T. Matsumoto, Y. Sasano, T. Takahashi, R. Sawada, K. Takahashi, K. Takahashi, T. Hamasaki, T. Kimura, T.
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Journal Title
Int J Gynecol Cancer
Volume: 24
Pages: 829-837
DOI
Peer Reviewed
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[Journal Article] A case of neonatal alloimmune thrombocytopenia in the presence of both anti-HPA-4b and anti-HPA-5b antibody: clinical and serological analysis of the subsequent pregnancy2014
Author(s)
Kiyokawa, T. Koh, Y. Mimura, K. Nakayama, K. Hosokawa, M. Sakuragi, M. Morikawa, T. Nakao, M. Aochi, H. Fukumori, Y. Kanagawa, T. Nagamine, K. Kimura, T. Tomiyama, Y.
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Journal Title
Int J Hematol
Volume: 100
Pages: 398-401
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Uterine cervical cancer displaying tumor-related leukocytosis: a distinct clinical entity with radioresistant feature2014
Author(s)
Mabuchi, S. Matsumoto, Y. Kawano, M. Minami, K. Seo, Y. Sasano, T. Takahashi, R. Kuroda, H. Hisamatsu, T. Kakigano, A. Hayashi, M. Sawada, K. Hamasaki, T. Morii, E. Kurachi, H. Matsuura, N. Kimura, T.
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Journal Title
J Natl Cancer Inst
Volume: 106
Pages: dju147
DOI
Peer Reviewed
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[Journal Article] Guidelines for obstetrical practice in Japan: Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2014 edition2014
Author(s)
Minakami, H. Maeda, T. Fujii, T. Hamada, H. Iitsuka, Y. Itakura, A. Itoh, H. Iwashita, M. Kanagawa, T., et al.
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Journal Title
J Obstet Gynaecol Res
Volume: 40
Pages: 1469-1499
DOI
Peer Reviewed
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[Journal Article] Three-dimensional sonography in the differential diagnosis of interstitial, angular, and intrauterine pregnancies in a septate uterus2014
Author(s)
Tanaka, Y. Mimura, K. Kanagawa, T. Kajimoto, E. Takahashi, K. Kakigano, A. Fujita, S. Kinugasa-Taniguchi, Y. Endo, M. Kimura, T.
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Journal Title
J Ultrasound Med
Volume: 33
Pages: 2031-2035
DOI
Peer Reviewed
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[Presentation] Mechanism responsible for the chemoresistance of uterine cervical cancer displaying tumor-related leukocytosis2014
Author(s)
Kawano, M. Mabuchi, S. Matsumoto, Y. Sasano, T. Takahashi, R. Kuroda, H. Hashimoto, K. Isobe, A. Sawada, K. Sakata, M. Kimura, T.
Organizer
15th Biennial Meeting of The International Gynecologic Cancer Society
Place of Presentation
Melbourne, Australia
Year and Date
2014-11-08 – 2014-11-11
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[Presentation] Maternal arterial stiffness in normotensive and chronically hypertensive women who subsequently delivered babies with small-for-gestational age2014
Author(s)
Tomimatsu, T. Fujime, M. Kanayama, T. Mimura, K. Koyama, S. Kanagawa, T. Endo, M. Shimoya, K. Kimura, T.
Organizer
46th International Congress on Pathophysiology of Pregnancy
Place of Presentation
Tokyo, JAPAN
Year and Date
2014-09-18 – 2014-09-20
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[Presentation] Immune tolerance induction using chorionic villus sampling (CVS) technique in rodent models2014
Author(s)
Endo, M. Takahashi, K. Miyoshi, T. Tsuritani, M. Shimazu, Y. Fujita, S. Kakigano, A. Taniguchi, Y. Mimura, K. Kanagawa, T. Hosoda, H. Kimura, T. Tamai, K. Yoshimatsu, J.
Organizer
24th World Congress on Ultrasound in Obstetrics and Gynecology
Place of Presentation
Barcelona, Spain
Year and Date
2014-09-14 – 2014-09-17
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[Presentation] The effect of raloxifene hydrochloride for the prevention of health care problems of patients who underwent surgeries for endometrial cancer: A multicenter clinical trial2014
Author(s)
Nakamura, K. Sawada, K. Sugiyama, M. Mabuchi, S. Hisamatsu, T. Nishio, Y. Ito, K. Kimura, T. Kamiura, S. Morishige, K.
Organizer
50th Annual Meeting of the American Society of Clinical Oncology
Place of Presentation
Chicago, U.S.A.
Year and Date
2014-05-30 – 2014-06-03
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