ＶＣＰ阻害剤による眼疾患に対する新たな神経保護治療法の研究開発

Products Report

• Project/Area Number: 24249082
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: YOSHIMURA Nagahisa 京都大学, 医学(系)研究科(研究院), 教授 (70211662)
• Co-Investigator(Kenkyū-buntansha): IKEDA Ohashi Hanako 京都大学, 医学部附属病院, 准教授 (20372162) ; KAKIZUKA Akira 京都大学, 大学院生命科学研究科, 教授 (80204329) ; IMAMURA Hiromi 京都大学, 白眉センター, 特定准教授 (20422545)
• Project Period (FY): 2012-10-31 – 2015-03-31

Research Products

• [Journal Article] KUS121, an ATP regulator, mitigates chorioretinal pathologies in animalmodels of age-related macular degeneration. (2018)
  • Author(s): Muraoka, Y., Yoshimura, N., et al.
  • Journal Title: Heliyon Volume: 4 Pages: e00624
  • DOI: 10.1016/j.heliyon.2018.e00624
  • Open Access
• [Journal Article] Modulation of valosin-containing protein by Kyoto University Substances (KUS) as a novel therapeutic strategy for ischemic neuronal diseases. (2017)
  • Author(s): Hata, M. & Ikeda, H. O.
  • Journal Title: Neural regeneration research Volume: 12 Pages: 1252-1255
  • DOI: 10.4103/1673-5374.213540
  • Open Access
• [Journal Article] KUS121, a VCP modulator, attenuates ischemic retinal cell death viasuppressing endoplasmic reticulum stress. (2017)
  • Author(s): Hata, M., Yoshimura, N., et al.
  • Journal Title: Scientific reports Volume: 7 Pages: 44873
  • DOI: 10.1038/srep44873
  • Open Access
• [Journal Article] Changes in morphology and visual function over time in mouse models of retinal degeneration : an SD-OCT, histology, and electroretinography study. (2016)
  • Author(s): Hasegawa, T., Yoshimura, N., et al.
  • Journal Title: Japanese journal of ophthalmology Volume: 60 Pages: 111-125
  • DOI: 10.1007/s10384-015-0422-0
  • Open Access
• [Journal Article] Neurprotective efficacies by KUS121, a VCP modulator, on animal models of retinal degeneration. (2016)
  • Author(s): Hasegawa, T. Yoshimura, N., et al.
  • Journal Title: Scientific reports Volume: 6 Pages: 31184
  • DOI: 10.1038/srep31184
  • Open Access
• [Journal Article] Neuroprotective effects of VCP modulators in mouse models of glaucoma. (2016)
  • Author(s): Nakano, N., Yoshimura, N., et al.
  • Journal Title: Heliyon Volume: 2 Pages: 96
  • DOI: 10.1016/j.heliyon.2016.e00096
  • Open Access
• [Patent(Industrial Property Rights)] 虚血性眼疾患の処置および/または予防用の医薬組成物 (2015)
  • Inventor(s): 垣塚彰、池田華子、吉村長久, 他1名
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Industrial Property Number: PCT/JP2015/055619
  • Filing Date: 2015-02-26
  • Overseas
• [Patent(Industrial Property Rights)] 眼疾患処置薬 (2014)
  • Inventor(s): 垣塚彰、池田華子、吉村長久, 他1名
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 14754749
  • Filing Date: 2014-02-19
  • Acquisition Date: 2017-12-22
• [Patent(Industrial Property Rights)] 眼疾患処置薬 (2011)
  • Inventor(s): 垣塚彰、堀清次、池田華子、吉村長久, 他3名
  • Industrial Property Rights Holder: 国立大学法人京都大学、他一社
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 5822840
  • Filing Date: 2011-09-30
  • Acquisition Date: 2015-10-16