Investigation of the reasons why Mongolia has few patients with cleft lip and/or palate: the assessment of a preventive effect of dairy products

2016 Fiscal Year Final Research Report

• Project/Area Number: 24256006
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Surgical dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: NATSUME Nagato 愛知学院大学, 歯学部, 教授 (90183532)
• Co-Investigator(Renkei-kenkyūsha): FURUKAWA Hiroo 愛知学院大学, 心身科学部, 教授 (70291763) ; NIIMI Teruyuki 愛知学院大学, 歯学部, 准教授 (70291763) ; MINAMI Katsuhiro 愛知学院大学, 歯学部, 講師 (70346162) ; SAKAI Eiko 愛知学院大学, 心身科学部, 教授 (80148254) ; YAMANAKA Katsumi 名古屋学芸大学, 栄養学部, 教授 (40351209) ; OTSUKA Takanobu 名古屋市立大学, 医学研究科, 教授 (10185316) ; SENDA Akira 愛知学院大学, 歯学部, 教授 (80097584) ; HATTORI Masami 愛知学院大学, 歯学部, 教授 (50113072) ; MAEDA Hatsuhiko 愛知学院大学, 歯学部, 教授 (30175591) ; INOUE Makoto 愛知学院大学, 薬学部, 教授 (50191888) ; IKEDA Yayoi 愛知学院大学, 歯学部, 教授 (00202903) ; SHIMAZAKI Yoshihiro 愛知学院大学, 歯学部, 教授 (10291519) ; MITANI Akio 愛知学院大学, 歯学部, 教授 (50329611) ; NOMOTO Shuji 愛知学院大学, 歯学部, 教授 (40300967) ; TAKEBE Jun 愛知学院大学, 歯学部, 教授 (50295995) ; FUJITANI Morioki 愛知学院大学, 歯学部, 教授 (60190055) ; YOSHIDA Waka 愛知学院大学, 歯学部, 講師 (10513210) ; HAYAKAWA Toko 愛知学院大学, 心身科学部, 講師 (90609710) ; IMURA Hideto 愛知学院大学, 歯学部, 講師 (10513187)
• Research Collaborator: YAMAUCHI Fuko ; NAGATA Erika ; AKASHI Junko ; ITO Masaaki ; NATSUME Nagana
• Project Period (FY): 2012-04-01 – 2017-03-31
• Keywords: モンゴル / 口唇裂 / 口蓋裂 / 乳製品 / 予防 / 先天異常の予防 / チーズの効果 / 疫学研究

Outline of Final Research Achievements

(1)Epidemiological investigation of the relationship between the eating habits and occurrence of cleft lip and/or palate (CL/P) in Mongolia.　Significant differences were observed in the intake of dairy products, meat and eggs by mothers of CL/P patients from that by mothers of normal children, suggesting the intake of those food may have the effect of preventing the occurrence of CL/P.Smoking habits of mothers of CL/P patients were also different from mothers of children without CL/P. There could be a possibility that smoking habits affect the occurrence of CL/P.
(2)Confirmation of the effect of Mongolian cheese on occurrence of CL/P in A/J mice.　The percentage of dead fetuses was 7.1% in the experimental group of A/J mice fed with Mongolian cheese, which was significantly 20.6% in the control group.As for incidence of CL/P, the incidence of CL/P in the experimental group was 6.5%, which was significantly lower than 11.7% of that in the control group (p=0.041).

Free Research Field

口腔外科学