Does physical exercise have a capacity for inducing the differentiation from white adipocytes to brown adipocytes ?: its application to prevent or cure obesity

2014 Fiscal Year Final Research Report

• Project/Area Number: 24300223
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Kyorin University
• Principal Investigator: OHNO Hideki 杏林大学, 医学部, 名誉教授 (00133819)
• Co-Investigator(Renkei-kenkyūsha): KIZAKI Takako 杏林大学, 医学部, 教授 (00322446) ; SAKURAI Takuya 杏林大学, 医学部, 講師 (20353477) ; OGASAWARA Junetsu 杏林大学, 医学部, 助教 (20415110)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 褐色脂肪細胞 / 運動 / 分化 / 白色脂肪細胞

Outline of Final Research Achievements

The purpose of the current study was to investigate the effect of habitual physical exercise training (ET) on browning, which results in producing brite adipocytes, of mature white adipocytes in several white adipose tissues from rats. In both inguinal and retroperitoneal adipose tissue, ET, which was loaded for 10 weeks, has shown to provoke the browning of white adipocytes. Under these conditions, levels of marker molecules of brite adipocytes and transcription modulating factors such as PRDM16 and/or PPAR were significantly elevated compared with sedentary control. It has been shown that browning of inguinal adipocytes might be related with the alteration in levels of activin receptor mRNA, although browning of retroperitoneal adipocytes might depend on changes in BMP7 mRNA. It was suggested, thus, that ET might have an ability to induce the browning of white adipose cells on these tissues through its region-specific modification events.

Free Research Field

運動生理学