Exercise and sex steroid hormones in skeletal muscle.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24300235
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: University of Tsukuba
• Principal Investigator: MESAKI Noboru 筑波大学, 名誉教授 (30010408)
• Co-Investigator(Kenkyū-buntansha): IEMITSU Motoyuki 立命館大学, スポーツ健康科学部, 教授 (90375460) ; SATO Koji 立命館大学, スポーツ健康科学部, 助教 (20584022) ; AIZAWA Katsuji 専修大学, 文学部, 准教授 (80375477)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 性ステロイドホルモン / 骨格筋 / 加齢 / レジスタンストレーニング

Outline of Final Research Achievements

Skeletal muscle can synthesize testosterone and 5α-dihydrotestosterone (DHT) from dehydroepiandrosterone (DHEA) via steroidogenic enzymes, but hormone levels and steroidogenic enzyme expression decline with aging. However, it remains unclear whether resistance training can restore impaired steroidogenic enzyme expressions in older individuals. In this study, muscular sex steroid hormone levels and sex steroidgenesis-related enzyme expressions were significantly lower in older subjects than younger ones at baseline, but 12 wk of resistance training significantly restored hormone levels (each P<0.05). Furthermore, the steroidogenesis-related enzymes such as 3β-hydroxysteroid dehydrogenase (HSD), 17β-HSD, and 5α-reductase expressions were significantly restored by resistance training. We conclude progressive resistance training restores age-related declines in sex steroidogenic enzyme and muscle sex steroid hormone levels in older men.

Free Research Field

女性スポーツ医学