Verification of relationships between dysfunction of the cell stress-protection system by exposures to multiple environmental chemicals and diseases

2015 Fiscal Year Final Research Report

• Project/Area Number: 24310046
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: University of Toyama
• Principal Investigator: Tabuchi Yoshiaki 富山大学, 研究推進機構 研究推進総合支援センター, 教授 (20322109)
• Co-Investigator(Kenkyū-buntansha): HOSHI Nobuhiko 神戸大学, (連合)農学研究科(研究院), 教授 (10209223) ; KONDO Takashi 富山大学, 大学院医学薬学研究部(医学), 教授 (40143937)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 内分泌かく乱物質

Outline of Final Research Achievements

Using immortalized oral epithelial cells, we have identified genes and gene networks involved in sodium fluoride-elicited cell death accompanying endoplasmic reticulum stress. In a mouse experimental model, the behavioral and reproductive effects of clothianidine, a neonicotinoid pesticide, became serious in combination with environmental stress, which may reflect our actual situation of multiple exposure. These findings obtained here will provide a basis for understanding the molecular mechanisms of combined influences by exposures to multiple environmental chemicals in mammals.

Free Research Field

細胞生理学