Development of Synthesis of Nano-Capsules for Medical Imaging Diagnoses Using Dispersion/Aggregation Process

2014 Fiscal Year Final Research Report

• Project/Area Number: 24310085
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Nanomaterials/Nanobioscience
• Research Institution: Ibaraki University
• Principal Investigator: KOBAYASHI YOSHIO 茨城大学, 工学部, 教授 (40250849)
• Co-Investigator(Renkei-kenkyūsha): SATO Masahide 宇都宮大学, 工学研究科, 准教授 (10261504) ; SUZUKI Noboru 宇都宮大学, 工学研究科, 教授 (40134259) ; GONDA Kohsuke 東北大学, 医学系研究科, 教授 (80375435) ; GONDA Kohsuke 東北大学, 医学系研究科, 教授 (90203710)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ナノ粒子 / カプセル / コア－シェル / 造影剤

Outline of Final Research Achievements

Luminescent semiconductor nanoparticles (QDs) are expected to be used as a fluorescent marker for medical diagnostics. Among various methods for reducing harm of Cd contained in QD, encapsulating, or coating of contrast agents with materials inert to living bodies is a good candidate. Meanwhile, materials that have both properties of fluorescence and X-ray absorption will be used for imaging targets by multiple techniques. The present work developed methods for preparing the QDs coated with silica (QD/SiO2), the QD/SiO2 particles on which Au nanoparticles were immobilized (QD/SiO2/Au particles), and the QD/SiO2/Au particles coated with silica (QD/SiO2/Au/SiO2 multi-layered particles).

Free Research Field

化学工学、材料化学