2014 Fiscal Year Final Research Report
Mechanical control of gene expression and its biological siginificance
| Project/Area Number |
24370085
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 細胞力覚 / 遺伝子発現 |
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| Outline of Final Research Achievements |
As observed as severe muscular atrophy of astronauts in micro-gravity situation, a loss of mechanical stimuli causes failure of homeostasis maintenance. However, molecular mechanisms by which cells and tissues sense physical force stimuli are largely unknown. In this research, we have identified several force-sensitive factors that control gene expression in living tissues. By extensive analyses, we now know that these factors play essential roles in cardiac development, maintenance of circulatory homeostasis, energy metabolism wound healing/regeneration. Our data provide fundamental insights into the disuse syndrome of astronauts and bedridden old patients, obesity/diabetes and their therapeutic approaches.
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| Free Research Field |
分子生物学、発生生物学
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