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2015 Fiscal Year Final Research Report

Analysis of coenzyme Q biosynthesis in eukaryotes

Research Project

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Project/Area Number 24380056
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Applied biochemistry
Research InstitutionShimane University

Principal Investigator

KAWAMUKAI MAKOTO  島根大学, 生物資源科学部, 教授 (70186138)

Co-Investigator(Kenkyū-buntansha) KAINO Tomohiro  島根大学, 生物資源科学部, 准教授 (90541706)
Co-Investigator(Renkei-kenkyūsha) MATSUO Yasuhiro  島根大学, 生物資源科学部, 助教 (70596832)
Research Collaborator YANAI Ryota  
MOCHIZUKI Shiomi  
YOKOMI Kazumasa  
Project Period (FY) 2012-04-01 – 2016-03-31
KeywordsコエンザイムQ / ユビキノン / 分裂酵母 / 抗酸化物質
Outline of Final Research Achievements

Coenzyme Q is essential for energy production through the electron transfer system and also acts as antioxidant. This study aims to understand the biosynthetic pathway of coenzyme Q in fission yeast. This analysis also contributes an understanding of human disease involved in CoQ synthesis. When we expressed genes for CoQ biosynthesis from human or plant into fission yeast, they complemented the function of fission yeast corresponding deletion mutants. The analysis of intermediate compounds accumulated in coq mutant was succeeded. The binding site of CoQ10 protein was unveiled in this study.

Free Research Field

遺伝子工学

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Published: 2017-05-10  

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