Molecular anatomy concerning autoimmune diseases and sterilities -relationship between onset of diseases and spermatogenetic checkpoint-

2014 Fiscal Year Final Research Report

• Project/Area Number: 24380156
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Hokkaido University
• Principal Investigator: KON Yasuhiro 北海道大学, (連合)獣医学研究科, 教授 (10178402)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 自己免疫疾患 / モデルマウス / 不妊症 / 精子形成

Outline of Final Research Achievements

MRL/MpJ mouse is known as an autoimmune disease and abnormal spermatogenesis model. In this study, spermatogenetic checkpoint function in the blood testis barrier (BTB) was analyzed by using this mouse.
Claudin3 was located to a spermatocyte at the time of the BTB passage, and the BTB passage was controlled by its expression. As the responsibility gene of testicular oocytes was located to the first chromosome, its relations with the autoimmune disease were doubted. As a result of vitamin A deficiency, the BTB was regarded as structure to take the differentiation adjustment of the spermatogenetic germ cells. It was shown by the heat shock that there were a BTB failure-resistant factor and a calcification remission factor on the chromosomes 1 and 11. Particularly, the telomere domain of MRL chromosome 1 is important, and the identification of the candidate gene is interested in future.

Free Research Field

獣医解剖学