2015 Fiscal Year Final Research Report
Study on the edible vaccine for chickens using recombinant barley with beta-glucanase
| Project/Area Number |
24380164
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAKAWA TAKASHI 東京大学, 大学院農学生命科学研究科, 教授 (20134520)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 家禽 / 食べるワクチン / ベータグルカナーゼ / ニューカッスル病ウイルス / オオムギ |
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| Outline of Final Research Achievements |
The production of barley carrying F or HN genes of Newcastle disease virus (NDV) to use as edible vaccine was planned. Antigenicity of F protein as well as experimental NDV infection system of chicken was established. Establishment of NDV F and HN producing barley could not be obtained, however, virological evidences such as the recognition of NDV virion by antibody raised to N-terminal fragment of F protein and neutralizing antibody inducing potential by HR1-immunization have been obtained.
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| Free Research Field |
獣医免疫学
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