Development of imaging probe to detect lipid derived radicals from whole body to cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390011
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Kyushu University
• Principal Investigator: YAMADA Kenichi 九州大学, 薬学研究科(研究院), 准教授 (60346806)
• Co-Investigator(Kenkyū-buntansha): KOBORI Yasuhiro 神戸大学, 大学院理学研究科, 教授 (00282038)
• Co-Investigator(Renkei-kenkyūsha): AOKI Ichio 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (10319519) ; MIURA Daisuke 九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (40532627)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 薬学 / 生体分子 / 脂質 / ストレス

Outline of Final Research Achievements

Lipid derived radicals and its metabolic products are closely involved in the pathogenesis of oxidative stress diseases such as inflammation and angiogenesis through the formation of protein or DNA complex. The starting point of lipid peroxide generation is lipid derived radicals which increase explosively via radical chain reaction. Therefore, the trapping of lipid derived radicals is useful to understanding the mechanism of formation of oxidative stress diseases, and to suppress the following chain reaction. On the other hands, nitroxides having stable unpaired electron allows spin trapping with carbon-centered radicals. Hence, in this study, we aimed to develop and evaluate lipid derived detection method using profluorescent nitroxide switching methods.

Free Research Field

薬学