2014 Fiscal Year Final Research Report
Analysis of novel cGMP pathway regulating innate immune responses
| Project/Area Number |
24390014
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
|
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| Research Institution | Tohoku University |
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Principal Investigator |
|
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 自然免疫 / cGMP / ショウジョウバエ |
|---|
| Outline of Final Research Achievements |
A receptor-type guanylate cyclase, Gyc76C, is a novel receptor regulating innate immune responses. Gyc76C regulates the activation of humoral responses in cGMP-dependent manner, and the activation of cellular responses in cGMP-independent manner. This study identified several Gyc76C down-stream factors involving the Gyc76C-mediated activation of humoral responses, and the Gyc76C-mediated activation of cellular responses.
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| Free Research Field |
生物系薬学
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