Investigation of pathophysiological roles of transporter for antioxidant with an aim to develop pharmacotherapeutics of inflammatory organ diseases

2015 Fiscal Year Final Research Report

• Project/Area Number: 24390040
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Kanazawa University
• Principal Investigator: Kato Yukio 金沢大学, 薬学系, 教授 (30251440)
• Co-Investigator(Renkei-kenkyūsha): SAKAI Yoshio 金沢大学, 医学系, 准教授 (80401925) ; WAKAYAMA Tomohiko 金沢大学, 医学系, 准教授 (70305100) ; NAKAMICHI Noritaka 金沢大学, 薬学系, 准教授 (10401895) ; SUGIURA Tomoko 金沢大学, 薬学系, 助教 (70542190)
• Research Collaborator: MASUO Yusuke 金沢大学, 薬学系, 助教 (90708140)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 薬物動態 / 膜輸送体 / 慢性臓器疾患 / 薬物治療 / 抗酸化物質

Outline of Final Research Achievements

The purpose of the present project is to establish the strategy to prevent and/or treat with chronic inflammatory diseases in various organs using a certain transporter which is highly expressed in the diseased lesions. Transporters are generally involved in membrane transport (influx and/or efflux) of their substrates. Therefore, transporters highly expressed in diseased lesions could be a possible target which can be used to prevent and/or treat with the corresponding diseases. This project has revealed that a certain transporter is highly expressed in diseased lesions of liver fibrosis and inflammatory bowel disease models, and that the transporter is involved in uptake of a food-derived naturally occurring antioxidant in the diseased organs, leading to suppression of deterioration of those diseases. Thus, the present findings have proposed a new strategy for pharmacotherapy of those diseases using potent antioxidant and/or thepeutic agents targeted to the transporter.

Free Research Field

薬物動態学