Stabilizing endocrine cell function by phogrin.

2015 Fiscal Year Final Research Report

• Project/Area Number: 24390050
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Gunma University
• Principal Investigator: TORII SEIJI 群馬大学, 生体調節研究所, 准教授 (40312904)
• Co-Investigator(Renkei-kenkyūsha): GOMI Hiroshi 日本大学, 生物資源科学部, 教授 (90293240) ; NAMEKI Nobukazu 群馬大学, 工学研究科, 准教授 (80302959) ; MOGAMI Hideo 浜松大学, 健康科学部, 教授 (90311604)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: ペプチドホルモン / 分泌顆粒 / インスリン / オートクライン / チロシンホスファターゼ

Outline of Final Research Achievements

Phogrin, a member of receptor protein tyrosine phosphatases, primarily localizes on secretory granules (SGs) in a variety of neuroendocrine cells including pancreatic β-cells, and has some supportive roles in SGs formation and cell growth. We analyze its function with use of newly developed imaging method and of gene-targeting mice. Our data show an evidence suggesting that at the plasma membrane phogrin participates in molecular interactions with insulin receptors to regulate IRS2 protein stability and in turn glucose-promoted pancreatic β-cell growth. We further showed that phogrin supports PTP1B activity to achieve an overall regulation of glucose-stimulated insulin signaling.

Free Research Field

神経内分泌細胞学