2014 Fiscal Year Final Research Report
Comprehensive analysis of TRIM type ubiquitin ligases in cell proliferation and differentiation
| Project/Area Number |
24390065
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TSUKIYAMA Tadasuke 北海道大学, 大学院医学研究科, 助教 (20399819)
TAKAHASHI Hidehisa 北海道大学, 大学院医学研究科, 講師 (30423544)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 細胞内シグナル伝達 |
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| Outline of Final Research Achievements |
TRIM family ubiquitin ligases are important for regulation of carcinogenesis in several cancers. It has been reported that TRIM family ubiquitin ligases regulate the activity of transcription factors in the process of cell proliferation and differentiation. By using proteomics analysis, we comprehensively analyzed TRIM family ubiquitin ligases which are related to ubiquitination of transcription factors. The analysis clarified the molecular mechanism in carcinogenesis of several cancers, maybe leading to the contribution to clinical applications for diagnosis and therapies.
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| Free Research Field |
医歯薬学
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