2014 Fiscal Year Final Research Report
Regulation of ectodomian shedding by ADAM17 and remnant signaling
Project/Area Number |
24390074
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
General medical chemistry
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Research Institution | Ehime University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
FUKUDA Shinji 愛媛大学, プロテオサイエンスセンター, 助教 (70398238)
INOUE Hirofumi 愛媛大学, 大学院医学系研究科, 講師 (70321635)
MATSUSHITA Natsuki 愛媛大学, 医学部附属病院, 研究員 (40271556)
JHO Takashi 名古屋市立大学, 大学院医学系研究科, 教授 (30231369)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | ectodomian shedding / ADAM17 / proHB-EGF / proamphiregulin / proTNF-α / annexin / レムナントペプチドシグナル |
Outline of Final Research Achievements |
ADAM17, a transmembrane-type metalloprotease, sheds various transmembrane proteins on cell surface, which regulates cell signaling. Both type I transmembrane protein proHB-EGF and proAREG, and type II transmembrane protein proTNF-α are equally shed. However, ADAM17 binding proteins annexin reversibly affected on their ADAM17-induced shedding. We propose that the catalytic domain of ADAM17 can swing by binding different member of annexin and access to the different types of membrane proteins.
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Free Research Field |
生化学、分子細胞生物学、
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