2014 Fiscal Year Final Research Report
Study on dynamics and function of basophils by using intravital imaging
| Project/Area Number |
24390093
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KARASUYAMA Hajime 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (60195013)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 好塩基球 / 生体イメージング / 細胞遊走 / マスト細胞 / 脱顆粒 |
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| Outline of Final Research Achievements |
We have established Mcpt8GFP mice in that only basophils express green fluorescence protein (GFP), making it possible to visualize the localization and migration of basophils in vivo by using confocal microscopy. Analysis of these mice identified the interaction of basophils with monocytes and macrophages, and demonstrated that basophil-derived IL-4 acts on tissue-infiltrating monocytes to promote their differentiation to type 2 macrophages which play important roles in parasite expulsion and termination of inflammation.
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| Free Research Field |
免疫学
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