2015 Fiscal Year Final Research Report
The motion of novel strategy against tuberculosis based on the analysis of latent tuberculosis
| Project/Area Number |
24390106
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Niigata University (2013-2015)
Osaka City University (2012) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ATo Manabu 国立感染症研究所, 免疫部, 部長 (20392318)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 結核 / MDP1 / 潜在性結核 / 再燃 / 潜伏感染 / アセトアミド / 動物 / 抗酸菌 |
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| Outline of Final Research Achievements |
One third world human population is latently infected with, a major human pathogen, Mycobacterium tuberculosis. The eradication of persisting M. tuberculosis has been thought to be the most successful action against tuberculosis, because M. tuberculosis generally has no environmental or animal reservoirs. Although M. tuberculosis is a well adapted intracellular pathogen, we believe that maintaining latent state can prevent the disease. In order to realize it, knowing molecular mechanisms of latency and disease development is important. In this research we established the mouse latency and reactivation model utilizing M. tuberculosis 18b, of which growth is dependent on the presence of streptomycin. And we showed that artificial gene expression causes growth arrest of Mycobacterium. This may provide reasonable accommodation to prevent the disease progression by downshifting the M. tuberculosis growth in vivo.
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| Free Research Field |
細菌学
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