Cross-reactive antibodies to influenza virus hemagglutinins and their epitopes

2016 Fiscal Year Final Research Report

• Project/Area Number: 24390110
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Virology
• Research Institution: Hokkaido University
• Principal Investigator: Takada Ayato 北海道大学, 人獣共通感染症リサーチセンター, 教授 (10292062)
• Co-Investigator(Renkei-kenkyūsha): ITO Kimihito 北海道大学, 人獣共通感染症リサーチセンター, 教授 (60396314) ; IGARASHI Manabu 北海道大学, 人獣共通感染症リサーチセンター, 准教授 (10374240)
• Research Collaborator: YOSHIDA Reiko ; MURAMATSU Mieko ; MIYAMOTO Hiroko ; Wilson Ian
• Project Period (FY): 2012-04-01 – 2017-03-31
• Keywords: ウイルス / インフルエンザ / 亜型 / 抗体 / 中和 / 感染防御

Outline of Final Research Achievements

By focusing on a novel antiviral function (budding inhibition), we found potential roles of anti-hemagglutinin antibodies in cross-protective immunity against influenza A viruses with multiple HA subtypes. It was particularly noted that the comparison between IgG and IgA antibodies recognizing the same epitope on the HA molecule clearly demonstrated the greater potential of HA-specific IgA than IgG antibodies in antiviral activities. It was also attempted to modify antibody specificity by structure-based molecular simulation and production of recombinant antibodies.

Free Research Field

ウイルス学