Elucidation of herpesvirus entry mechanism identifying its host receptor

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390114
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Virology
• Research Institution: Kobe University
• Principal Investigator: MORI Yasuko 神戸大学, 医学(系)研究科(研究院), 教授 (50343257)
• Co-Investigator(Kenkyū-buntansha): TANG Huamin 神戸大学, 大学院医学研究科, 助教 (10595896)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: HHV-6 / ウイルス感染 / エントリー / 受容体

Outline of Final Research Achievements

Human herpesvirus 6B (HHV-6B) causes exanthem subitum in little children, and then establishes lifelong latency in the host. It can reactivate from latency in immunocompromised patients and usually causes severe diseases. No therapeutic or prophylactic methods for HHV-6B infection are available. In the current study, we focused on the entry process of HHV-6B, and identified the cellular receptor which had been unidentified. Furthermore, we did detailed analysis of the interaction between the novel pair of receptor and viral ligand, and found the key domains for their interaction. Our achievement would contribute to the elucidation of the molecular mechanism of HHV-6B infection.

Free Research Field

ウイルス学