Analysis of innate IL-5 producing cells in immune responses and chronic inflammation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390119
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Immunology
• Research Institution: University of Toyama
• Principal Investigator: TAKATSU Kiyoshi 富山大学, 大学院医学薬学研究部(医学), 客員教授 (10107055)
• Co-Investigator(Kenkyū-buntansha): NAGAI Yoshinori 富山大学, 大学院医学薬学研究部(医学), 客員准教授 (30431761) ; IKUTANI Masashi 富山大学, 大学院医学薬学研究部(医学), 客員講師 (40513718)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: サイトカイン / 自然免疫 / 粘膜免疫 / 免疫監視・腫瘍免疫

Outline of Final Research Achievements

In this study, we investigated the roles of innate IL-5-producing cells in the lung and the intestine by taking advantage of IL-5/Venus knock-in mice. In response to IL-25 or IL-33, innate IL-5-producing cells rapidly produced IL-5 and IL-13. These cells were localized around bronchus and bronchioles and recruited eosinophil into the lung, suggesting that innate IL-5-producing cells play a critical role in the pathogenesis of allergic conditions. Innate IL-5-producing cells in the lung also contributed to anti-tumor immunity via eosinophil regulation. On the other hand, in the large intestine, innate IL-5-producing cells contributed to T cell-independent IgA production.

Free Research Field

免疫学