Representation of pain in the central nervous system studied by simultaneous multicellular recording

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390148
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: University of Fukui
• Principal Investigator: MURASE Kazuyuki 福井大学, 工学(系)研究科(研究院), 教授 (40174289)
• Co-Investigator(Kenkyū-buntansha): FURUE Hideaki 生理学研究所, 神経シグナル研究部門, 准教授 (20304884)
• Co-Investigator(Renkei-kenkyūsha): IKEDA Hiroshi 福井大学, 大学院工学研究科, 教授 (80377473)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: in vivo多細胞記録 / カルシウムイメージング / 共焦点レーザー顕微鏡 / 痛覚 / 慢性疼痛

Outline of Final Research Achievements

For the induction of hyperalgesia and chronic pain, glial cells, in addition to neuronal plasticity in the spinal cord and brain, plays an important role. However, pain appears in different pathologies, and it is quite unclear how pain is expressed by excitation patterns in neurons and glial cells in the spinal cord and brain. In this study, we tried to record excitation of multiple cells simultaneously in the spinal cord and the brain in vitro and in vivo by using a Nipkow disk confocal laser microscope, and to clarify how pain such as hyperalgesia is expressed in the cellular activities.

Free Research Field

神経情報処理