2015 Fiscal Year Final Research Report
Depression and interaction between occupational stress and genetic/epigenetic factors
| Project/Area Number |
24390160
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kitasato University (2015)
Research Institute, International Medical Center of Japan (2012-2014) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Tomoko 北里大学, 医学部, 助教 (60728682)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | メンタルヘルス / 抑うつ / ストレス / エピゲノム / 遺伝子 |
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| Outline of Final Research Achievements |
This study was conducted in order to make the foundation of mental prevention by clarifying the interaction between occupational stress and genetic/epigenetic factors. 774 volunteers were recruited. As an epigenetic information which relates to depression, we reported the methylation proportions of BDNF gene(Am J Med Genet B 2014) and MTHFR gene(J Neurol Neurol Disord 2015) as possible useful markers. As an epigenetic information which relates to occupational stress, we reported the methylation proportions of TH gene(J Neurol Neurol Disord 2015) as a possible useful marker.
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| Free Research Field |
公衆衛生学
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