Molecular epidemiology study of inflammation-associated disease development on the basis of long-term follow-up of atomic-bomb survivors

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390162
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Hygiene
• Research Institution: Radiation Effects Research Foundation
• Principal Investigator: HAYASHI Tomonori 公益財団法人放射線影響研究所, 放射線生物学/分子疫学部, 副部長 (70333549)
• Co-Investigator(Kenkyū-buntansha): TOKUNAGA Katsushi 東京大学, 大学院医学系研究科, 教授 (40163977)
• Co-Investigator(Renkei-kenkyūsha): NAKACHI Kei 公益財団法人放射線影響研究所, 顧問 (00142117) ; OGAWA Takahiko 公益財団法人放射線影響研究所, 放射線生物学/分子疫学部, 研究員 (90399626)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ゲノム / 放射線 / 炎症 / 活性酸素 / 分子疫学 / 遺伝子多型 / 放射線感受性 / 免疫

Outline of Final Research Achievements

We examined the effect of genetic background on radiation-related cancer development regarding gastric (intestinal and diffuse types) cancer, colorectal (proximal and distal colorectal) cancer, and breast cancer among atomic bomb (A-bomb) survivors. As a result, we found that IL10 genotypes may be associated with the development of radiation-related diffuse-type gastric cancer, that CD14 and IL18 genotypes may be associated with radiation-related distal colorectal and proximal colon cancers, respectively, and that ATM genotypes may be associated with radiation-related breast cancer.
We investigated the effects of age and radiation exposure on ROS levels in blood cells derived from A-bomb survivors. As a results we found that ROS levels in CD8+ T cells in particular increased with age and radiation dose and that those levels were significantly different by IL6R genotypes.

Free Research Field

分子疫学