Life-course genetic epidemiological research of adult disease using intergenerational longitudinal twin family data

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390167
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Ishikawa Prefectural Nursing University
• Principal Investigator: OOKI Syuichi 石川県立看護大学, 看護学部, 教授 (00303404)
• Co-Investigator(Renkei-kenkyūsha): HIKO Kiyomi 石川県立看護大学, 看護学部, 准教授 (80531912)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 双生児 / 胎内環境仮説 / ライフコース遺伝疫学 / 世代間伝達 / 生態学的モデル / レコードリンケージ / 生殖補助医療 / 先天異常

Outline of Final Research Achievements

Developmental Origin of Health and Disease (DOHaD) hypothesis was verified using two intergenerational longitudinal twin family databases from perinatal to adult period. The influence of assisted reproductive technology was intensively analyzed as candidate environmental marker of perinatal and early life period. It was suggested that DOHaD hypothesis is not necessarily applicable in the same manner as singletons in twins in early childhood. But, DOHaD hypothesis was applicable in twins in the long term. The reason was unclear whether this was adoption mechanism specific to twins.

Free Research Field

医歯薬学　社会医学