2014 Fiscal Year Final Research Report
PET imaging using a novel tracer to detect amyloidosis
| Project/Area Number |
24390179
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | アミロイド / PET |
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| Outline of Final Research Achievements |
In order to visualize amyloid deposition in the myocardium, patients underwent a cardiac positron-emission tomography（PET） study with [11C]-BF-227. The PET images revealed significantly robust retention of [11C]-BF-227 in the patients' hearts compared with that of the normal control. In any of the amyloidgenic disorders, such as transthyretin-related systemic amyloidosis and Alzheimer’s disease, it is surmised that the monomer of the amyloid protein itself is not very toxic, whereas misfolded oligomers could cause damage to human organs. It is therefore truly important to detect the accumulation of real amyloid fibrils for the early and accurate diagnosis of amyloidosis. It is therefore truly important to detect the accumulation of real amyloid fibrils for the early and accurate diagnosis of amyloidosis. To our knowledge, this is the first report showing the usefulness of beta-pleated sheet structure-specific PET in investing visceral organ amyloidosis.
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| Free Research Field |
老年医学
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