New analytical technology in the field of pathology clarified effectiveness of Kampo formula

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390181
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: The University of Tokushima (2014); University of Toyama (2012-2013)
• Principal Investigator: TSUNEYAMA Koichi 徳島大学, ヘルスバイオサイエンス研究部, 教授 (10293341)
• Co-Investigator(Kenkyū-buntansha): FUJIMOTO Makoto 富山大学, 大学病院, 講師 (30377337)
• Co-Investigator(Renkei-kenkyūsha): TAIRA Shu 福井県立大学, 生物資源学部, 准教授 (30416672)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: メタボリックシンドローム / NASH / 動物モデル / 漢方薬 / 質量顕微鏡

Outline of Final Research Achievements

The number of patients with metabolic syndrome (MetS) and its liver phenotype, non-alcoholic steatohepatitis (NASH) were rapidly increased in all over the world, however no heroic drug was established. We noted to Kampo formula, medicinal herb and natural products to cure of MetS and/or NASH. We firstly established new animal models of MetS/NASH which is mimic to human disease process and pathology. For the analysis of effectiveness and function, we induced imaging mass spectrometry which is a new analytical technology of pathology. We examined several Kampo formula and so on, and succeeded to make clarify the effectiveness of Keishi-bukuryo-gan, Boi-ohgi-to, red yeast rice, spirulina, daily coffee intake against MetS/NASH. We also highlighted their ingredients, phycocyanin and GABA, which showed unique physiological function. Activation of macrophages is one of a key events to exert their function.

Free Research Field

実験病理学