2014 Fiscal Year Final Research Report
A role of p53-induced senescence in life style-related disease
| Project/Area Number |
24390195
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 老化 / p53 / 生活習慣病 |
|---|
| Outline of Final Research Achievements |
The prevalence of obesity, diabetes and heart failure increases with aging, and there is evidence that these age-related disorders share common pathologic features such as chronic low-grade inflammation and systemic metabolic dysfunction. Cellular senescence was initially discovered by in vitro studies, but it is now widely accepted that this process also occurs in vivo with aging. The p53 signaling pathway has a central role in the regulation of cellular senescence, and our study indicates that cellular senescence has a causative role in the progression of age-related disorders, such as diabetes, vascular aging, and heart failure.
|
| Free Research Field |
循環器内科
|
