2014 Fiscal Year Final Research Report
Development of a novel vascular-targeting therapy through stem cell research
| Project/Area Number |
24390197
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
YAMASHITA Jun 京都大学, iPS細胞研究所, 教授 (50335288)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 血管新生 / 多能性幹細胞 / 内皮細胞 / 分化 / 血管内皮増殖因子 / アンジオポイエチン |
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| Outline of Final Research Achievements |
Purpose of this study is that development of novel therapies for ischemic heart disease or cancer through manipulating vascular formation using advanced pluripotent stem cell research.
We demonstrated that kappa-opioid receptor suppressed tumor angiogenesis through inhibiting expression of type II vascular endothelial growth factor receptor. In addition, we reported a novel function of angiopoietin-1 in coronary vein formation as a collaboration with Department of cardiovascular medicine, University of Tokyo.
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| Free Research Field |
循環器内科学
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