2014 Fiscal Year Final Research Report
The role of endothelial IRS in the regulation of glucose uptake by muscle during exercise and arteriosclerosis
| Project/Area Number |
24390232
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KUBOTA Naoto 東京大学, 医学部附属病院, 准教授 (50396719)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | インスリン受容体基質 |
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| Outline of Final Research Achievements |
Insulin-stimulated phosphorylation of Akt and eNOS were significantly impaired in the endothelium from endothelial cell specific IRS-1/IRS2 double deficient mice. In these mice, glucose uptake by skeletal muscle during exercise was significantly decreased, suggesting that endothelial IRSs were crucial roles in the regulation of glucose metabolism during exercise. Moreover, neointima formation and arteriosclerosis were significantly exacerbated in endothelial cell specific IRS-2 knockout mice, suggesting that IRS-2 was important for protection of atherosclerosis in the endothelium.
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| Free Research Field |
糖尿病代謝
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