Progranulin, a Novel HDL-Binding Protein, Suppresses Systemic Inflammation, Glucose Abnormality and Atherosclerosis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390233
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Osaka University
• Principal Investigator: YAMASHITA Shizuya 大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (60243242)
• Co-Investigator(Kenkyū-buntansha): MASUDA Daisaku 大阪大学, 大学院医学系研究科, 特任助教 (20568753)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: プログラニュリン / マクロファージ / 炎症

Outline of Final Research Achievements

While progranulin (PGRN) has been reported to be involved with cell proliferation, wound healing and inflammation, there were no direct information on the association of progranulin with atherosclerosis. Therefore, we crossed apoE-knockout(KO) mce with PGRN-KO mice to generate double-KO (DKO) mice. DKO mice exhibit more severe atherosclerosis compared with apoE-KO mice. Considering PGRN is associated with various inflammatory diseases, PGRN can be a novel therapeutic target for atherosclerotic and inflammatory diseases.

Free Research Field

動脈硬化、脂質代謝