2014 Fiscal Year Final Research Report
Role for novel innate immune receptors for pulmonary pathogens
| Project/Area Number |
24390256
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kagoshima University (2014)
Saga University (2012-2013) |
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Principal Investigator |
HARA Hiromitsu 鹿児島大学, 医歯(薬)学総合研究科, 教授 (20392079)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUZAKI Goro 琉球大学, 熱帯生物圏研究センター, 教授 (30229455)
YAMASAKI Sho 九州大学, 生体防御医学研究所, 教授 (40312946)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 自然免疫 / 結核 |
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| Outline of Final Research Achievements |
We identified two novel innate immune receptors, IgMB1 and IgMB2, that recognize Mycobacterium tuberculosis. We found that IgMB1 recognizes non-glycosylated mycolates (MA) such as GroMM and free MA and induces MCP-1, but not TNF, production by macrophages, whereas the CLR Mince recognizes the glycosylated-mycolates, TDM and GMM, and induces both TNF and MCP-1 production. In addition, we found that IgMB1 inhibits the cytokine responses through Mincle in macrophages.We also identified a novel innate immune receptor, IgRF1, that recognizes influenza virus. We found that the innate cytokine response through IgRF1 contributes to influenza pneumonia.
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| Free Research Field |
免疫学
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