2014 Fiscal Year Final Research Report
Role of imflammasome in IgA nephropathy
| Project/Area Number |
24390265
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Koichi 和歌山県立医科大学, 医学部, 講師 (50336880)
SHIMA Yuko 和歌山県立医科大学, 医学部, 助教 (60433364)
TOGAWA Hiroko 和歌山県立医科大学, 医学部, 博士研究員 (30445093)
MUKAIYAMA Hironobu 和歌山県立医科大学, 医学部, 助教 (70549740)
HAMA Taketsugu 和歌山県立医科大学, 医学部, 助教 (00508020)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | IgA腎症 / インフラマソーム / NLRP3 / caspase 1 / IL-1β / IL-18 |
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| Outline of Final Research Achievements |
We analyzed gene expression of NLRP3 inflammasome and IL-1 beta, IL-18 produced as a result of activation using renal biopsy tissue of IgA nephropathy patients to clarify it whether NLRP3 inflammasome had a role for glomerulus inflammation in IgA nephropathy.
We examined NLRP3, CASP1 (caspase 1), IL-1 beta and IL-18 gene expression in renal biopsy tissue from IgA nephropathy patients (severe type and mild type, before and after 2-year therapy) and those with asymptomatic proteinuria (controls).
As a result, NLRP3, CASP1, IL-1 beta showed a significant difference between controls with the patients, and the contribution to a disease episode was suggested, and basic data of the disease specific therapy was obtained.
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| Free Research Field |
小児腎臓病学
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